ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2017
A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- S1PR1 signaling biases neutrophils toward long-lived low-inflammatory functional states.bioRxiv : the preprint server for biology · 2026Article
- Alteration of microbial composition in the skin and blood in vasculitis.Scientific reports · 2023Article
- Dissecting the Therapeutic Mechanisms of Sphingosine-1-Phosphate Receptor Agonism during Ischaemia and Reperfusion.International journal of molecular sciences · 2023Article
- Review
- Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.Cancers · 2021Article
- Pathogens in Vasculitis: Is It Really Idiopathic?JMA journal · 2021Review
- Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.The Journal of clinical investigation · 2019Article
- Sphingosine-1-phosphate receptors and innate immunity.Cellular microbiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSphingosine 1-phosphate (S1P) is a bioactive lipid that binds to cell surface receptors (S1P
methodsMice were administered ONO-W061, and the number of peripheral blood cells was counted. Vasculitis was induced by an intraperitoneal injection of CAWS. Expression of S1P receptors and CXCL1 was analyzed by quantitative RT-PCR. ONO-W061 was orally administered, and vasculitis was evaluated histologically. Number of neutrophils, macrophages and T cells in the vasculitis tissue was counted using flow cytometry. Production of chemokines from S1P-stimulated human umbilical vein endothelial cells (HUVECs) was measured by ELISA.
resultsNumber of peripheral blood lymphocytes was decreased by ONO-W061. Expression of CXCL1 and S1P
conclusionsONO-W061 significantly improved CAWS-induced vasculitis. This effect may be partly exerted through the inhibited production of chemokines by endothelial cells, which in turn could induce neutrophil recruitment into inflamed vessels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.