Evidence map›Paper›PMID 27942674›Full record

ArticleOrganic & biomolecular chemistry2017

Conformationally superarmed S-ethyl glycosyl donors as effective building blocks for chemoselective oligosaccharide synthesis in one pot.

Mithila D Bandara, Jagodige P Yasomanee, Nigam P Rath, Christian M Pedersen, Mikael Bols, Alexei V Demchenko

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Approaches to stereoselective 1,1'-glycosylation.Beilstein journal of organic chemistry · 2025
    Review
  4. Bromine-Promoted Glycosidation of Conformationally Superarmed Thioglycosides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019
    Article
  5. Review
  6. Regenerative Glycosylation.The Journal of organic chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mithila D BandaraDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. demchenkoa@umsl.edu.
Jagodige P YasomaneeDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. demchenkoa@umsl.edu.
Nigam P RathDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. demchenkoa@umsl.edu.
Christian M PedersenDepartment of Chemistry, University of Copenhagen, 2100 Copenhagen Ø, Denmark.ORCID http://orcid.org/0000-0003-4661-4895
Mikael BolsDepartment of Chemistry, University of Copenhagen, 2100 Copenhagen Ø, Denmark.
Alexei V DemchenkoDepartment of Chemistry and Biochemistry, University of Missouri - St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA. demchenkoa@umsl.edu.ORCID http://orcid.org/0000-0003-3515-212X

Funding

Automation of the chemical synthesis of human milk oligosaccharidesR01GM111835 · NIGMS · SAINT LOUIS UNIVERSITY · PI DEMCHENKO, ALEXEI V · 2014 to 2023
$2.5M
NIGMS NIH HHS R01 GM111835
6 · The paper itself

Abstract

A new series of superarmed glycosyl donors has been investigated. It was demonstrated that the S-ethyl leaving group allows for high reactivity, which is much higher than that of equally equipped S-phenyl glycosyl donors that were previously investigated by our groups. The superarmed S-ethyl glycosyl donors equipped with a 2-O-benzoyl group gave complete β-stereoselectivity. Utility of the new glycosyl donors has been demonstrated in a one-pot one-addition oligosaccharide synthesis with all of the reaction components present from the beginning.

Indexed as

Carbohydrate ConformationGlycosidesGlycosylationOligosaccharidesStereoisomerismGlycosidesOligosaccharides

Identifiers

PMID27942674
PMCPMC5496005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.