ArticleJCI insight2016
Interleukin 6 regulates psoriasiform inflammation-associated thrombosis.
Open access · goldAbstract read
In one paragraph
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Restoration of Keratinocyte Homeostasis Drives Resolution of Skin Inflammation.bioRxiv : the preprint server for biology · 2026Article
- From skin to heart: a state-of-the-art perspective on psoriasis-driven cardiovascular comorbidities.Frontiers in immunology · 2026Review
- G-CSF Mediates Increased Renal Neutrophils and Kidney Damage in a Psoriasis Mouse Model.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Cardiovascular disease risk in psoriatic disease: mechanisms and implications for clinical practice.Current opinion in rheumatology · 2025Review
- Circulating, Extracellular Vesicle-Associated Tissue Factor in Cancer Patients with and without Venous Thromboembolism.Biomolecules · 2025Article
- Early Cerebral Microvasculature Impairment and Increased Body Mass Index in Patients with Psoriasis.Biomedicines · 2024Article
- Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Under the dual effect of inflammation and pulmonary fibrosis, CTD-ILD patients possess a greater susceptibility to VTE.Thrombosis journal · 2024Review
- Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.JCI insight · 2024Article
- Network pharmacology prediction and molecular docking-based strategy to discover the potential pharmacological mechanism of Huang-Qi-Gui-Zhi-Wu-Wu decoction against deep vein thrombosis.Journal of orthopaedic surgery and research · 2023Article
- TheJournal of inflammation research · 2023Article
- Prediction and verification of the effect of psoriasis on coronary heart disease based on artificial neural network.Heliyon · 2022Article
- Mouse Models of Psoriasis: A Comprehensive Review.The Journal of investigative dermatology · 2022Review
- Impact of Chronic Inflammation in Psoriasis on Bone Metabolism.Frontiers in immunology · 2022Review
- Psoriasis and Cardiovascular Disease: Novel Mechanisms and Evolving Therapeutics.Current atherosclerosis reports · 2021Review
- New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine.The Journal of investigative dermatology · 2021Review
- Interleukin-17 and Interleukin-23: A Narrative Review of Mechanisms of Action in Psoriasis and Associated Comorbidities.Dermatology and therapy · 2021Review
- Meeting Report: 68The Journal of investigative dermatology · 2020Article
- Massive pulmonary embolism following recovery from COVID-19 infection: inflammation, thrombosis and the role of extended thromboprophylaxis.BMJ case reports · 2020Article
- Post-traumatic pulmonary embolism: incidence, physiopathology, risk factors of early occurrence, and impact outcome. A narrative review.American journal of cardiovascular disease · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Yunmei WangDivision of Cardiovascular Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Jackelyn B GoldenDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Yi FritzDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Xiufen ZhangDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Doina DiaconuDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Maya I CamhiDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Huiyun GaoDivision of Cardiovascular Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Sean M DawesDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Xianying XingDepartment of Dermatology.
Santhi K GaneshDepartment of Internal Medicine, Division of Cardiovascular Medicine, and Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Johann E GudjonssonDepartment of Dermatology.
Daniel I SimonDivision of Cardiovascular Medicine, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, USA.
Thomas S McCormickDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Nicole L WardDepartment of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
Case Western Reserve University · USUniversity Hospitals of Cleveland · US
Funding
Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1MSystems Biology CoreP50AR055508 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI DIAZ-INSUA, MIREYA · 2007 to 2011
$6.8MInflammation in Vascular Injury and RepairR37HL057506 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SIMON, DANIEL I · 2007 to 2016
$4.1MInflammation in Vascular Injury and RepairR01HL057506 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SIMON, DANIEL I · 1997 to 2006
$2.4MRole of IL-13 and the IL-13 Associated rs20541 Risk Variant in the Pathogenesis of PsoriasisR01AR069071 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2015 to 2019
$2.1MMRP-14, CD36 and ThrombosisR01HL126645 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI SIMON, DANIEL I · 2016 to 2019
$2.0MIL-17C mediated mechanisms of inflammationR01AR062546 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 2013 to 2017
$1.9MRemote Inflammation and AtherothrombosisR01AR063437 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 2012 to 2016
$1.7MRole of the Psoriasis Associated IL23R Risk Variants on Th17 Biology and FunctionK08AR060802 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GUDJONSSON, JOHANN ELI · 2011 to 2015
$636kNeurogenic inflammation and psoriasiform dermatitisR21AR063852 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 2013 to 2014
$370kNHLBI NIH HHS R01 HL057506NHLBI NIH HHS R01 HL126645NIAMS NIH HHS K08 AR060802NIAMS NIH HHS P30 AR039750NIAMS NIH HHS P50 AR055508NIAMS NIH HHS R01 AR062546NIAMS NIH HHS R01 AR063437NIAMS NIH HHS R01 AR069071NIAMS NIH HHS R21 AR063852
Abstract
Psoriasis patients are at increased risk of heart attack and stroke and have elevated MRP8/14 levels that predict heart attack. The KC-Tie2 psoriasiform mouse model exhibits elevated MRP8/14 and is prothrombotic.
Indexed as
AnimalsCalgranulin BFemaleHumansInflammationInterleukin-23Interleukin-6KeratinocytesMaleMiceMice, Inbred C57BLMice, KnockoutPsoriasisReceptor, TIE-2ThrombosisCalgranulin BInterleukin-23Interleukin-6Receptor, TIE-2Tek protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.