ArticleNeuroImage. Clinical2017
Impact of schizophrenia on anterior and posterior hippocampus during memory for complex scenes.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Hippocampal subregion abnormalities in schizophrenia: A systematic review of structural and physiological imaging studies.Neuropsychopharmacology reports · 2018Pooled it
- Modulation of hippocampal activity in schizophrenia with levetiracetam: a randomized, double-blind, cross-over, placebo-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Review
- st-DenseViT: A Weakly Supervised Spatiotemporal Vision Transformer for Dense Prediction of Dynamic Brain Networks.Human brain mapping · 2025Article
- Tests of abnormal gaze behavior increase the accuracy of mild cognitive impairment assessments.Scientific reports · 2024Article
- Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus.Scientific reports · 2024Article
- The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Altered developmental trajectories of verbal learning skills in 22q11.2DS: associations with hippocampal development and psychosis.Psychological medicine · 2023Article
- Maternal Immune Activation Induces Adolescent Cognitive Deficits Preceded by Developmental Perturbations in Cortical Reelin Signalling.Biomolecules · 2023Article
- Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers.Current topics in behavioral neurosciences · 2023Article
- Memory-Based Prediction Deficits and Dorsolateral Prefrontal Dysfunction in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study.Schizophrenia research · 2022Article
- MicroRNAs in the Onset of Schizophrenia.Cells · 2021Review
- Slow wave activity moderates the association between new learning and traumatic brain injury severity.Sleep · 2021Article
- Disordered directional brain network interactions during learning dynamics in schizophrenia revealed by multivariate autoregressive models.Human brain mapping · 2020Article
- Glutamic acid decarboxylase 67 haplodeficiency in mice: consequences of postweaning social isolation on behavior and changes in brain neurochemical systems.Brain structure & function · 2020Article
- Anterior Hippocampal-Cortical Functional Connectivity Distinguishes Antipsychotic Naïve First-Episode Psychosis Patients From Controls and May Predict Response to Second-Generation Antipsychotic Treatment.Schizophrenia bulletin · 2020Article
- Cognition and Reward Circuits in Schizophrenia: Synergistic, Not Separate.Biological psychiatry · 2020Review
- Hyperactivity and Reduced Activation of Anterior Hippocampus in Early Psychosis.The American journal of psychiatry · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesHippocampal dysfunction has been proposed as a mechanism for memory deficits in schizophrenia. Available evidence suggests that the anterior and posterior hippocampus could be differentially affected. Accordingly, we used fMRI to test the hypothesis that activity in posterior hippocampus is disproportionately reduced in schizophrenia, particularly during spatial memory retrieval.
methods26 healthy participants and 24 patients with schizophrenia from the UC Davis Early Psychosis Program were studied while fMRI was acquired on a 3 Tesla Siemens scanner. During encoding, participants were oriented to critical items through questions about item features (e.g., "Does the lamp have a square shade?") or spatial location (e.g., "Is the lamp on the table next to the couch?"). At test, participants determined whether scenes were changed or unchanged. fMRI analyses contrasted activation in a priori regions of interest (ROI) in anterior and posterior hippocampus during correct recognition of item changes and spatial changes.
resultsAs predicted, patients with schizophrenia exhibited reduced activation in the posterior hippocampus during detection of spatial changes but not during detection of item changes. Unexpectedly, patients exhibited increased activation of anterior hippocampus during detection of item changes. Whole brain analyses revealed reduced fronto-parietal and striatal activation in patients for spatial but not for item change trials.
conclusionsResults suggest a gradient of hippocampal dysfunction in which posterior hippocampus - which is necessary for processing fine-grained spatial relationships - is underactive, and anterior hippocampus - which may process context more globally - is overactive.
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Registered trials
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