Evidence map›Paper›PMID 27942449›Full record

ArticleNeuroImage. Clinical2017

Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy.

Ravnoor Singh Gill, Seyed M Mirsattari, L Stan Leung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Protective Effect ofIranian journal of pharmaceutical research : IJPR · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ravnoor Singh GillGraduate Program in Neuroscience, Western University, London, Ontario, Canada; Department of Physiology & Pharmacology, Western University, London, Ontario, Canada.
Seyed M MirsattariGraduate Program in Neuroscience, Western University, London, Ontario, Canada; Clinical Neurological Sciences, Western University, London, Ontario, Canada; Department of Biomedical Imaging, Western University, London, Ontario, Canada; Department of Biomedical Physics, Western University, London, Ontario, Canada; Department of Psychology, Western University, London, Ontario, Canada.
L Stan LeungGraduate Program in Neuroscience, Western University, London, Ontario, Canada; Department of Physiology & Pharmacology, Western University, London, Ontario, Canada.
Western University · CA

Funding

CIHR MOP-15685
6 · The paper itself

Abstract

We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed as networks in epileptic and control rats. Graph theoretical analysis revealed a significant increase in functional connectivity between brain areas in epileptic than control rats, and the connected brain areas could be categorized as a limbic network and a default mode network (DMN). The limbic network includes the hippocampus, amygdala, piriform cortex, nucleus accumbens, and mediodorsal thalamus, whereas DMN involves the medial prefrontal cortex, anterior and posterior cingulate cortex, auditory and temporal association cortex, and posterior parietal cortex. The TLE model manifested a higher clustering coefficient, increased global and local efficiency, and increased small-worldness as compared to controls, despite having a similar characteristic path length. These results suggest extensive disruptions in the functional brain networks, which may be the basis of altered cognitive, emotional and psychiatric symptoms in TLE.

Indexed as

AnimalsCerebral CortexConnectomeDisease Models, AnimalEpilepsy, Temporal LobeExcitatory Amino Acid AgonistsKainic AcidLimbic SystemMaleNerve NetRatsRats, Long-EvansExcitatory Amino Acid AgonistsKainic AcidDefault mode networkFunctional connectivityKainic acidLimbic systemResting-state networksTemporal lobe epilepsy

Identifiers

PMID27942449
PMCPMC5133653
OpenAlexW2548099112

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.