Molecular linkage tracing of HIV-1 transmission events in seroconcordant couples in Guangxi Province, Southeastern China.

Nidan Wang, Zhenzhu Tang, Yijia Li, Peiyan Xie, Yiming Shao

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Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Nidan Wang *State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Zhenzhu Tang *Guangxi Center for Disease Prevention and Control, Nanning, People's Republic of China.

Yijia LiDepartment of Infectious Diseases, Peking Union Medical College Hospital, Beijing, People's Republic of China.

Peiyan XieState Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Yiming ShaoState Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.

Funding

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6 · The paper itself

Abstract

backgroundGuangxi Province in Southeastern China has one of the highest HIV-1 infection and transmission rates in stable couples. However, the mode of transmission at the molecular level has seldom been reported amongst this group. It is important to investigate this issue to support the treatment-as-prevention approach and for efficient interventions.

methodsHIV-1 subgenomic regions (1.2 kb of

resultsThirty-five pairs (83.3 %, 35/42) were identified as linked, 3 pairs (7.1 %, 3/42) were identified as indeterminate, and 4 pairs (9.5 %) were identified as unlinked. The predominant intra-couple-transmitted HIV-1 subtype was CRF01_AE (80 %, 28/35). The median genetic distance of linked couples was 0.5 %.

conclusionThe majority of HIV-1 transmission events in this study occurred within the partnership, and the predominant HIV-1 subtype was CRF01_AE. Further research on the mode of HIV transmission in other locations is needed.

Indexed as

HIV-1 transmissionPhylogenetic analysis, Bayesian analysisSeroconcordant couplesSerodiscordant couples

Identifiers

PMID27942427

DOI10.1186/s40064-016-3578-2

PMCPMC5124024

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