ArticleIntegrative obesity and diabetes2016
Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity.
Article in Integrative obesity and diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Interaction between anNutrients · 2018Trial
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- The impact of testosterone on paraventricular nucleus gene expression in male and female spontaneously hypertensive rats.Biology of sex differences · 2026Article
- Central leptin pathways in metabolic homeostasis.Clinical science (London, England : 1979) · 2025Review
- Protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors sex-dependently in rats.Obesity (Silver Spring, Md.) · 2025Article
- Whole Exome Sequencing Revealed Paternal Inheritance of Obesity-related Genetic Variants in a Family with an Exclusively Breastfed InfantJournal of clinical research in pediatric endocrinology · 2024Article
- Functional Evaluation of a Novel Homozygous ADCY3 Variant Causing Childhood Obesity.International journal of molecular sciences · 2024Article
- A multi-modal framework improves prediction of tissue-specific gene expression from a surrogate tissue.EBioMedicine · 2024Article
- Protein-coding mutation inbioRxiv : the preprint server for biology · 2024Article
- Anti-miR-141-3p maintains homeostasis between autophagy and apoptosis by targeting Yy1 in the fetal lumbosacral defecation center of rats.Molecular therapy. Nucleic acids · 2024Article
- Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder.Physiological genomics · 2024Review
- Neuronal primary cilia integrate peripheral signals with metabolic drives.Frontiers in physiology · 2023Review
- Mechanisms of Weight Control by Primary Cilia.Molecules and cells · 2022Review
- Physiological roles of mammalian transmembrane adenylyl cyclase isoforms.Physiological reviews · 2022Review
- Neuronal cilia in energy homeostasis.Frontiers in cell and developmental biology · 2022Review
- Hypothalamic primary cilium: A hub for metabolic homeostasis.Experimental & molecular medicine · 2021Review
- The BBSome: a nexus controlling energy metabolism in the brain.The Journal of clinical investigation · 2021Article
- Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.eLife · 2020Article
- Neuronal and astrocytic primary cilia in the mature brain.Pharmacological research · 2018Review
- ADCY3, neuronal primary cilia and obesity.Nature genetics · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Evidence from human studies and transgenic mice lacking the type 3 adenylyl cyclase (AC3) indicates that AC3 plays a role in the regulation of body weight. It is unknown in which brain region AC3 exerts such an effect. We examined the role of AC3 in the hypothalamus for body weight control using a floxed AC3 mouse strain. Here, we report that AC3 flox/flox mice became obese after the administration of AAV-CRE-GFP into the hypothalamus. Both male and female AC3 floxed mice showed heavier body weight than AAV-GFP injected control mice. Furthermore, mice with selective ablation of AC3 expression in the ventromedial hypothalamus also showed increased body weight and food consumption. Our results indicated that AC3 in the hypothalamus regulates energy balance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.