Evidence map›Paper›PMID 27942286›Full record

ArticleGastroenterology research2010

A RecQ Protein-like 5 Haplotype is Associated With Colon Cancer.

Heather M Ochs-Balcom, Cheryl L Thompson, Sarah Plummer, Guangbin Luo, Thomas C Tucker, Graham Casey, Li Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Heather M Ochs-BalcomDepartment of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, New York, 14214, USA; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Cheryl L ThompsonDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 44106, USA; Department of Family Medicine, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio, 44106, USA; Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Sarah PlummerDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, 90089, USA.
Guangbin LuoDepartment of Genetics, Case Western Reserve University, 44106, Cleveland, Ohio, USA.
Thomas C TuckerCancer Control Program, University of Kentucky, Lexington, Kentucky, 40536, USA.
Graham CaseyDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, 90089, USA.
Li LiDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, 44106, USA; Department of Family Medicine, Case Western Reserve University/University Hospitals Case Medical Center, Cleveland, Ohio, 44106, USA; Case Center for Transdisciplinary Research on Energetics and Cancer, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
University at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging murine model data suggests RecQ protein-like 5 (

methodsWe examined the association of two haplotype-tagging SNPs in

resultsWhile both crude and covariate-adjusted single SNP analyses were only suggestive for an association with borderline significance (p = 0.07), haplotype analysis shows that individuals carrying the T-G haplotype (rs820196 common allele and rs4789223 minor allele) were at significantly increased risk for colon cancer (OR = 1.34, 95% CI = 1.02-1.76, p = 0.05). Adjustment for age, sex, body mass index, non-steroidal anti-inflammatory use and family history of colon cancer did not alter the results.

conclusionsThese results suggest that a haplotype harboring the minor allele of rs4789223 is associated with colon cancer risk. Further study of

Indexed as

Colon cancerHaplotypeRECQL5Single Nucleotide Polymorphism

Identifiers

PMID27942286
PMCPMC5139762
OpenAlexW2170601697

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.