ArticleAdvanced functional materials2016
Multi-Material Tissue Engineering Scaffold with Hierarchical Pore Architecture.
Article in Advanced functional materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Growth factors-infused cellulose scaffolds support cost-efficient proliferation and differentiation of bovine stem cells for cultivated meat.Current research in food science · 2026Article
- Methacrylated poly(glycerol sebacate) as a photocurable, biocompatible, and biodegradable polymer with tunable degradation and drug release kinetics.Drug delivery and translational research · 2025Article
- Poly(glycerol succinate) hydrogel promotes spinal cord repair by regulating bio-energetic activity in severe injury.Materials today. Bio · 2025Article
- Elastomeric Polyesters in Cardiovascular Tissue Engineering and Organs-on-a-Chip.Biomacromolecules · 2023Review
- Cells and Materials for Cardiac Repair and Regeneration.Journal of clinical medicine · 2023Review
- Artificial Scaffolds in Cardiac Tissue Engineering.Life (Basel, Switzerland) · 2022Review
- Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration.NPJ Regenerative medicine · 2021Article
- Poly(Glycerol Sebacate) in Biomedical Applications-A Review of the Recent Literature.Advanced healthcare materials · 2021Review
- Fabrication and Biomedical Applications of Heart-on-a-chip.International journal of bioprinting · 2021Review
- Ultrathin Dual-Scale Nano- and Microporous Membranes for Vascular Transmigration Models.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Dual Porosity Protein-based Scaffolds with Enhanced Cell Infiltration and Proliferation.Scientific reports · 2018Article
- Engineered circulatory scaffolds for building cardiac tissue.Journal of thoracic disease · 2018Review
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- Spatially and Temporally Controlled Hydrogels for Tissue Engineering.Materials science & engineering. R, Reports : a review journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Multi-material polymer scaffolds with multiscale pore architectures were characterized and tested with vascular and heart cells as part of a platform for replacing damaged heart muscle. Vascular and muscle scaffolds were constructed from a new material, poly(limonene thioether) (PLT32i), which met the design criteria of slow biodegradability, elastomeric mechanical properties, and facile processing. The vascular-parenchymal interface was a poly(glycerol sebacate) (PGS) porous membrane that met different criteria of rapid biodegradability, high oxygen permeance, and high porosity. A hierarchical architecture of primary (macroscale) and secondary (microscale) pores was created by casting the PLT32i prepolymer onto sintered spheres of poly(methyl methacrylate) (PMMA) within precisely patterned molds followed by photocuring, de-molding, and leaching out the PMMA. Pre-fabricated polymer templates were cellularized, assembled, and perfused in order to engineer spatially organized, contractile heart tissue. Structural and functional analyses showed that the primary pores guided heart cell alignment and enabled robust perfusion while the secondary pores increased heart cell retention and reduced polymer volume fraction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.