Evidence map›Paper›PMID 27942243›Full record

ArticleTropical medicine and health2016

Prevalence, seasonal variation, and antibiotic resistance pattern of enteric bacterial pathogens among hospitalized diarrheic children in suburban regions of central Kenya.

Mohammad Shah, Cyrus Kathiiko, Akihiro Wada, Erick Odoyo, Martin Bundi, Gabriel Miringu, Sora Guyo, Mohamed Karama, Yoshio Ichinose

Open access · goldAbstract read
In one paragraph

Article in Tropical medicine and health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mohammad ShahKenya Research Station, NUITM-KEMRI Project, Nagasaki University Institute of Tropical Medicine, P.O. Box 19993-00202, Nairobi, Kenya ; Centre for Infectious Disease Research in Asia and Africa, Nagasaki University Institute of Tropical Medicine, 1-12-4 Sakamoto, Nagasaki City, 852-8523 Japan ; Leading Graduate School Program, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki City, 852-8523 Japan.
Cyrus KathiikoKenya Research Station, NUITM-KEMRI Project, Nagasaki University Institute of Tropical Medicine, P.O. Box 19993-00202, Nairobi, Kenya.
Akihiro WadaDepartment of Bacteriology, Nagasaki University Institute of Tropical Medicine, 1-12-4 Sakamoto, Nagasaki City, 852-8523 Japan.
Erick OdoyoKenya Research Station, NUITM-KEMRI Project, Nagasaki University Institute of Tropical Medicine, P.O. Box 19993-00202, Nairobi, Kenya.
Martin BundiKenya Research Station, NUITM-KEMRI Project, Nagasaki University Institute of Tropical Medicine, P.O. Box 19993-00202, Nairobi, Kenya.
Gabriel MiringuKenya Research Station, NUITM-KEMRI Project, Nagasaki University Institute of Tropical Medicine, P.O. Box 19993-00202, Nairobi, Kenya.
Sora GuyoKenya Research Station, NUITM-KEMRI Project, Nagasaki University Institute of Tropical Medicine, P.O. Box 19993-00202, Nairobi, Kenya.
Mohamed KaramaCenter for Public Health Research, KEMRI, P.O. Box 19993-00202, Nairobi, Kenya.
Yoshio IchinoseKenya Research Station, NUITM-KEMRI Project, Nagasaki University Institute of Tropical Medicine, P.O. Box 19993-00202, Nairobi, Kenya ; Centre for Infectious Disease Research in Asia and Africa, Nagasaki University Institute of Tropical Medicine, 1-12-4 Sakamoto, Nagasaki City, 852-8523 Japan ; Department of Bacteriology, Nagasaki University Institute of Tropical Medicine, 1-12-4 Sakamoto, Nagasaki City, 852-8523 Japan ; Leading Graduate School Program, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki City, 852-8523 Japan.
Kenya Medical Research Institute · KENagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe epidemiology of enteric pathogens has not been well studied in Kenya because of wide disparities in health status across the country. Therefore, the present study describes the prevalence of enteropathogenic bacteria, their seasonal variation, and antibiotic resistance profiles among hospitalized diarrheic children in a suburban region of central Kenya.

methodsFecal samples were collected between July 2009 and December 2013 from a total of 1410 children younger than 5 years, hospitalized with acute diarrhea in Kiambu County Hospital, Kenya. Conventional culture, biochemical, and molecular methods were conducted to identify causative bacterial pathogens and their virulence factors. Antimicrobial susceptibility tests were performed using E-test strips and VITEK-2 advanced expert system (AES) to evaluate the drug-resistance pattern of the isolates.

resultsOf the 1410 isolates, bacterial infections were identified in 474 cases. Diarrheagenic

conclusionsThis study suggests that DEC is the leading diarrhea-causing bacterial pathogen circulating in central Kenya, and seasonality has a significant effect on its transmission. Proper antibiotic prescription and susceptibility testing is important to guide appropriate antimicrobial therapy.

Indexed as

Antimicrobial susceptibility patternDiarrheaE. coli pathotypesSeasonal variation

Identifiers

PMID27942243
PMCPMC5126808
OpenAlexW2558175969

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.