Evidence map›Paper›PMID 27942190›Full record

ArticleJournal of orthopaedics2017

Ang-2 but not Ang-1 expression in perivascular soft tissue tumors.

Swati Shrestha, Jia Shen, Paulina Giacomelli, Michelle A Scott, Chia Soo, Kang Ting, Bruno Péault, Sarah M Dry, Aaron W James

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Swati ShresthaSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jia ShenSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Paulina GiacomelliDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michelle A ScottNationwide Children's Hospital, Columbus, OH 43205, USA.
Chia SooOrthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Surgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kang TingSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Bruno PéaultOrthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Regenerative Medicine, University of Edinburgh, Edinburgh EH8 9JT, UK.
Sarah M DryDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Aaron W JamesSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Orthopedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology, Johns Hopkins University, Baltimore, MD 21279, USA.
University of California, Los Angeles · USNationwide Children's Hospital · USOrthopaedic Hospital · US

Funding

NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Medical Research Council MR/K017047/1NIAMS NIH HHS K08 AR068316
6 · The paper itself

Abstract

Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes. Previously, we reported a shared immunophenotype across these related tumor types. Here, we extend these findings to examine the expression of the pericyte markers angiopoietin-1 and -2 (Ang-1 and -2) among perivascular soft tissue tumors. Results showed consistent Ang-2 but not Ang-1 expression across tumor types. In summary, the absence of Ang-1 expression distinguishes perivascular from vascular soft tissue tumors. Ang-2 expression is present across perivascular soft tissue tumors, with some variation between histologic subtypes.

Indexed as

AngioleiomyomaAngiopoietinGlomus tumorMyopericytomaPericyte

Identifiers

PMID27942190
PMCPMC5134090
OpenAlexW2558724128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.