ArticlePloS one2016
Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- A systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.PLoS neglected tropical diseases · 2022Pooled it
- Dengue Virus Infection and Associated Risk Factors in Africa: A Systematic Review and Meta-Analysis.Viruses · 2021Pooled it
- Dengue Virus Infection in Sub-Saharan Africa Between 2010 and 2020: A Systematic Review and Meta-Analysis.Frontiers in cellular and infection microbiology · 2021Pooled it
- Chikungunya fever in Africa: a systematic review.Pathogens and global health · 2020Pooled it
- A decade of dengue disease burden in Africa (2013-2023): a systematic review.Travel medicine and infectious diseasePooled it
- Trial
- Pathogenesis and seroprevalence of dengue virus in HIV-endemic regions: A global perspective.New microbes and new infections · 2025Article
- Risk factors associated with dengue and chikungunya seroprevalence and seroconversion among urban populations in western and coastal Kenya.PLoS neglected tropical diseases · 2025Article
- Malaria survey data and geospatial suitability mapping for understanding spatial and temporal variations of risk across Kenya.Parasite epidemiology and control · 2025Article
- Current Epidemiological Status of Chikungunya Virus Infection in East Africa: A Systematic Review and Meta-Analysis.Journal of tropical medicine · 2024Review
- Factors enhancing the transmission of mosquito-borne arboviruses in Africa.Virusdisease · 2022Review
- Clinical and epidemiologic characteristics associated with dengue fever in Mombasa, Kenya.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Congenital microcephaly unrelated to flavivirus exposure in coastal Kenya.Wellcome open research · 2019Article
- Complete Genome Sequences of Dengue Virus Type 2 Strains from Kilifi, Kenya.Microbiology resource announcements · 2019Article
- The epidemiology of febrile illness in sub-Saharan Africa: implications for diagnosis and management.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2018Review
- Health worker knowledge of Integrated Disease Surveillance and Response standard case definitions: a cross-sectional survey at rural health facilities in Kenya.BMC public health · 2018Article
- Article
- Unrecognized Dengue Virus Infections in Children, Western Kenya, 2014-2015.Emerging infectious diseases · 2017Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundFever is common among patients seeking care in sub-Saharan Africa (sSA), but causes other than malaria are rarely diagnosed. We assessed dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV infection (AHI) and malaria in coastal Kenya.
methodsWe tested plasma samples obtained in a cross-sectional study from febrile adult patients aged 18-35 years evaluated for AHI and malaria at urgent care seeking at seven health facilities in coastal Kenya in 2014-2015. Dengue virus (DENV) and chikungunya virus (CHIKV) were amplified using quantitative real-time reverse-transcription polymerase chain reaction. We conducted logistic regression analyses to determine independent predictors of dengue virus infection.
results489 samples that were negative for both AHI and malaria were tested, of which 43 (8.8%, 95% confidence interval [CI]: 6.4-11.7) were positive for DENV infection. No participant was positive for CHIKV infection. DENV infections were associated with clinic visits in the rainy season (adjusted odds ratio (AOR) = 3.0, 95% CI: 1.3-6.5) and evaluation at a private health facility (AOR 5.2, 95% CI: 2.0-13.1) or research health facility (AOR = 25.6, 95% CI: 8.9-73.2) instead of a public health facility.
conclusionA high prevalence of DENV infections was found in febrile young adult patients evaluated for AHI. Our data suggests that DENV, along with AHI and malaria, should be considered in the differential diagnosis of the adult patient seeking care for fever in coastal Kenya.
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