ArticleScientific reports2016
A novel approach to quantify different iron forms in ex-vivo human brain tissue.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- MatchingFrontiers in neuroanatomy · 2019Pooled it
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- In-depth magnetometry and EPR analysis of the spin structure of human-liver ferritin: from DC to 9 GHz.Physical chemistry chemical physics : PCCP · 2023Article
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- Effects of fixatives on histomagnetic evaluation of iron in rodent spleen.Journal of magnetism and magnetic materials · 2021Article
- Sensitive SQUID Bio-Magnetometry for Determination and Differentiation of Biogenic Iron and Iron Oxide Nanoparticles in the Biological Samples.Nanomaterials (Basel, Switzerland) · 2020Article
- Effects of Alzheimer's disease and formalin fixation on the different mineralised-iron forms in the human brain.Scientific reports · 2020Article
- (-)-Epicatechin Reduces the Blood Pressure of Young Borderline Hypertensive Rats During the Post-Treatment Period.Antioxidants (Basel, Switzerland) · 2020Article
- Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies.Cell biochemistry and biophysics · 2019Article
- Distribution of magnetic remanence carriers in the human brain.Scientific reports · 2018Article
- Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects.Scientific reports · 2018Article
- Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury.Scientific reports · 2018Article
- Cortical Iron Reflects Severity of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a novel combination of methods to study the physical properties of ferric ions and iron-oxide nanoparticles in post-mortem human brain, based on the combination of Electron Paramagnetic Resonance (EPR) and SQUID magnetometry. By means of EPR, we derive the concentration of the low molecular weight iron pool, as well as the product of its electron spin relaxation times. Additionally, by SQUID magnetometry we identify iron mineralization products ascribable to a magnetite/maghemite phase and a ferrihydrite (ferritin) phase. We further derive the concentration of magnetite/maghemite and of ferritin nanoparticles. To test out the new combined methodology, we studied brain tissue of an Alzheimer's patient and a healthy control. Finally, we estimate that the size of the magnetite/maghemite nanoparticles, whose magnetic moments are blocked at room temperature, exceeds 40-50 nm, which is not compatible with the ferritin protein, the core of which is typically 6-8 nm. We believe that this methodology could be beneficial in the study of neurodegenerative diseases such as Alzheimer's Disease which are characterized by abnormal iron accumulation in the brain.
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