Evidence map›Paper›PMID 27941911›Full record

ArticleScientific reports2016

Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling.

Hui He, Fang Guo, Yong Li, Fatma Saaoud, Brooks D Kimmis, Jeena Sandhu, Michelle Fan, Dev Maulik, Susan Lessner, Christopher J Papasian and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  8. Trained Immunity and Reactivity of Macrophages and Endothelial Cells.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Hui HeInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
Fang GuoInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
Yong LiDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA.
Fatma SaaoudDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Brooks D KimmisDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA.
Jeena SandhuDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA.
Michelle FanDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA.
Dev MaulikDepartment of Obstetrics and Gynecology, University of Missouri - Kansas City School of Medicine, Kansas City, MO 64108, USA.
Susan LessnerDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Christopher J PapasianDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA.
Daping FanDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Zhisheng JiangInstitute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
Mingui FuDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA.
University of Missouri–Kansas City · USUniversity of South Carolina · USUniversity of South China · CN

Funding

Use of Resveratrol to treat experimental multiple sclerosisP01AT003961 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, PRAKASH S · 2007 to 2018
$14.2M
Sparstolonin B as an anti-atherogenic agentR01HL116626 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FAN, DAPING · 2013 to 2017
$1.7M
Post-transcriptional Regulation of Cytokine ProductionR21AI103618 · NIAID · UNIVERSITY OF MISSOURI KANSAS CITY · PI FU, MINGUI · 2014 to 2015
$415k
Pilot Study of Gender-specific Differences in Failure Resistance and Material Fatigue of Human Carotid Atherosclerotic PlaquesR03EB019663 · NIBIB · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LESSNER, SUSAN M · 2016 to 2017
$129k
NCCIH NIH HHS P01 AT003961NHLBI NIH HHS R01 HL116626NIAID NIH HHS R21 AI103618NIBIB NIH HHS R03 EB019663
6 · The paper itself

Abstract

Adiporedoxin (Adrx) is a recently discovered redox regulatory protein that is preferentially expressed in adipose tissue and plays a critical role in the regulation of metabolism via its modulation of adipocyte protein secretion. We here report that Adrx suppresses endothelial cell activation via inhibiting MAPK and NF-kB signaling pathways. Adrx is constitutively expressed in human vascular endothelial cells, and significantly induced by a variety of stimuli such as TNFα, IL-1β, H

Indexed as

MAP Kinase Signaling SystemPeroxiredoxinsArteriesCell AdhesionCell LineEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsIntercellular Adhesion Molecule-1MonocytesNF-kappa BPlaque, AtheroscleroticRNA, MessengerTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1Intercellular Adhesion Molecule-1NF-kappa BPeroxiredoxinsPRXL2A protein, humanRNA, MessengerTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID27941911
PMCPMC5150245
OpenAlexW2561911359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.