Evidence map›Paper›PMID 27941910›Full record

ArticleScientific reports2016

Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains of non-human primates using [

Kuo-Hsing Ma, Tsung-Ta Liu, Shao-Ju Weng, Chien-Fu F Chen, Yuahn-Sieh Huang, Sheau-Huei Chueh, Mei-Hsiu Liao, Kang-Wei Chang, Chi-Chang Sung, Te-Hung Hsu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kuo-Hsing MaDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Tsung-Ta LiuDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Shao-Ju WengDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Chien-Fu F ChenGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Yuahn-Sieh HuangDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Sheau-Huei ChuehDepartment of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Mei-Hsiu LiaoInstitute of Nuclear Energy Research, Taoyuan, Taiwan.
Kang-Wei ChangInstitute of Nuclear Energy Research, Taoyuan, Taiwan.
Chi-Chang SungDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Te-Hung HsuDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Wen-Sheng HuangDepartment of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Cheng-Yi ChengDepartment of Nuclear Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
National Defense Medical Center · TWInstitute of Nuclear Energy Research · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known to cause serotonergic neurotoxicity in the brain. Dextromethorphan (DM) is a widely used antitussive reported to exert anti-inflammatory effect in vivo. In this study, we examined the long-term effect of MDMA on the primate serotonergic system and the protective property of DM against MDMA-induced serotonergic abnormality using single photon emission computed tomography (SPECT). Nine monkeys (Macaca cyclopis) were divided into three groups, namely control, MDMA and co-treatment (MDMA/DM). [

Indexed as

AnimalsBrainCinanserinDextromethorphanIodine RadioisotopesMagnetic Resonance ImagingN-Methyl-3,4-methylenedioxyamphetaminePrimatesSerotoninTime FactorsTomography, Emission-Computed, Single-Photon2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamineCinanserinDextromethorphanIodine RadioisotopesN-Methyl-3,4-methylenedioxyamphetamineSerotonin

Identifiers

PMID27941910
PMCPMC5150522
OpenAlexW2564911043

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.