ArticleScientific reports2016
Chaos and Hyperchaos in a Model of Ribosome Autocatalytic Synthesis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- On the dynamical aspects of local translation at the activated synapse.BMC bioinformatics · 2020Article
- Bioinformatics research at SBB-2019.BMC bioinformatics · 2020Article
- Limit cycles in models of circular gene networks regulated by negative feedback loops.BMC bioinformatics · 2020Article
- Individual Copy Number of Ribosomal Genes as a Factor of Mental Retardation and Autism Risk and Severity.Cells · 2019Article
- Persister Cells - a Plausible Outcome of Neutral Coevolutionary Drift.Scientific reports · 2018Article
- Dynamic landscape of the local translation at activated synapses.Molecular psychiatry · 2018Article
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4 authors.
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Abstract
Any vital activities of the cell are based on the ribosomes, which not only provide the basic machinery for the synthesis of all proteins necessary for cell functioning during growth and division, but for biogenesis itself. From this point of view, ribosomes are self-replicating and autocatalytic structures. In current work we present an elementary model in which the autocatalytic synthesis of ribosomal RNA and proteins, as well as enzymes ensuring their degradation are described with two monotonically increasing functions. For certain parameter values, the model, consisting of one differential equation with delayed argument, demonstrates both stationary and oscillatory dynamics of the ribosomal protein synthesis, which can be chaotic and hyperchaotic dependent on the value of the delayed argument. The biological interpretation of the modeling results and parameter estimation suggest the feasibility of chaotic dynamics in molecular genetic systems of eukaryotes, which depends only on the internal characteristics of functioning of the translation system.
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