Evidence map›Paper›PMID 27941903›Full record

Trial reportScientific reports2016

A Novel Method for Estimating Myocardial Strain: Assessment of Deformation Tracking Against Reference Magnetic Resonance Methods in Healthy Volunteers.

Kenneth Mangion, Hao Gao, Christie McComb, David Carrick, Guillaume Clerfond, Xiaodong Zhong, Xiaoyu Luo, Caroline E Haig, Colin Berry

Abstract readClinical Trial
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. [Study on direct ventricular assist loading mode based on a finite element method].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024
    Article
  2. Article
  3. Bayesian optimisation for efficient parameter inference in a cardiac mechanics model of the left ventricle.International journal for numerical methods in biomedical engineering · 2022
    Article
  4. Article
  5. A poroelastic immersed finite element framework for modelling cardiac perfusion and fluid-structure interaction.International journal for numerical methods in biomedical engineering · 2021
    Article
  6. Article
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  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kenneth MangionBHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
Hao GaoSchool of Mathematics and Statistics, University of Glasgow, UK.
Christie McCombBHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
David CarrickWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Clydebank, UK.
Guillaume ClerfondBHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.
Xiaodong ZhongMR R&D Collaborations, Siemens Healthcare, Atlanta, GA, USA.
Xiaoyu LuoSchool of Mathematics and Statistics, University of Glasgow, UK.
Caroline E HaigRobertson Centre for Biostatistics, University of Glasgow, UK.
Colin BerryBHF Glasgow Cardiovascular Research Centre, University of Glasgow, UK.

Funding

British Heart Foundation FS/15/54/31639British Heart Foundation PG/11/2/28474British Heart Foundation PG/14/64/31043Chief Scientist Office SC01Medical Research Council MR/N003403/1
6 · The paper itself

Abstract

We developed a novel method for tracking myocardial deformation using cardiac magnetic resonance (CMR) cine imaging. We hypothesised that circumferential strain using deformation-tracking has comparable diagnostic performance to a validated method (Displacement Encoding with Stimulated Echoes- DENSE) and potentially diagnostically superior to an established cine-strain method (feature-tracking). 81 healthy adults (44.6 ± 17.7 years old, 47% male), without any history of cardiovascular disease, underwent CMR at 1.5 T including cine, DENSE, and late gadolinium enhancement in subjects >45 years. Acquisitions were divided into 6 segments, and global and segmental peak circumferential strain were derived and analysed by age and sex. Peak circumferential strain differed between the 3 groups (DENSE: -19.4 ± 4.8%; deformation-tracking: -16.8 ± 2.4%; feature-tracking: -28.7 ± 4.8%) (ANOVA with Tukey post-hoc, F-value 279.93, p < 0.01). DENSE and deformation-tracking had better reproducibility than feature-tracking. Intra-class correlation co-efficient was >0.90. Larger magnitudes of strain were detected in women using deformation-tracking and DENSE, but not feature-tracking. Compared with a reference method (DENSE), deformation-tracking using cine imaging has similar diagnostic performance for circumferential strain assessment in healthy individuals. Deformation-tracking could potentially obviate the need for bespoke strain sequences, reducing scanning time and is more reproducible than feature-tracking.

Indexed as

Myocardial ContractionAdultContrast MediaFemaleGadoliniumHeartHeart Function TestsHumansImage Processing, Computer-AssistedMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardiumOrgan SizeReference StandardsStress, MechanicalContrast MediaGadolinium

Identifiers

PMID27941903
PMCPMC5150576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.