ArticleNature nanotechnology2017
Targeted intracellular voltage recordings from dendritic spines using quantum-dot-coated nanopipettes.
Article in Nature nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 127 citations in OpenAlex.
- Intracellular neuronal recordings across DNA tiles.Nature nanotechnology · 2026Article
- Behavioral timescale synaptic plasticity: properties, elements and functions.Nature neuroscience · 2026Review
- Spine-neck electrical bottlenecks tune temporal precision and inhibitory gating in cortical pyramidal neurons: A connectomics-based biophysical study.bioRxiv : the preprint server for biology · 2026Article
- Optical segmentation-based compressed readout of neuronal voltage dynamics.Nature communications · 2025Article
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
- Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording.Microsystems & nanoengineering · 2025Article
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging.Cell reports · 2024Article
- Membrane-coated glass electrodes for stable, low-noise electrophysiology recordings in Drosophila central neurons.Journal of neuroscience methods · 2024Article
- Electrical properties of dendritic spines.Biophysical journal · 2023Review
- A GPU-based computational framework that bridges neuron simulation and artificial intelligence.Nature communications · 2023Article
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- Diversity of dynamic voltage patterns in neuronal dendrites revealed by nanopipette electrophysiology.Nanoscale · 2023Article
- Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity.Advances in neurobiology · 2023Article
- Toward implantable devices for angle-sensitive, lens-less, multifluorescent, single-photon lifetime imaging in the brain using Fabry-Perot and absorptive color filters.Light, science & applications · 2022Article
- Review
- Voltage compartmentalization in dendritic spines in vivo.Science (New York, N.Y.) · 2022Article
- Electrical recordings from dendritic spines of adult mouse hippocampus and effect of the actin cytoskeleton.Frontiers in molecular neuroscience · 2022Article
- Efficient Simulation of 3D Reaction-Diffusion in Models of Neurons and Networks.Frontiers in neuroinformatics · 2022Article
- Optical probing of local membrane potential with fluorescent polystyrene beads.Biophysical reports · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Dendritic spines are the primary site of excitatory synaptic input onto neurons, and are biochemically isolated from the parent dendritic shaft by their thin neck. However, due to the lack of direct electrical recordings from spines, the influence that the neck resistance has on synaptic transmission, and the extent to which spines compartmentalize voltage, specifically excitatory postsynaptic potentials, albeit critical, remains controversial. Here, we use quantum-dot-coated nanopipette electrodes (tip diameters ∼15-30 nm) to establish the first intracellular recordings from targeted spine heads under two-photon visualization. Using simultaneous somato-spine electrical recordings, we find that back propagating action potentials fully invade spines, that excitatory postsynaptic potentials are large in the spine head (mean 26 mV) but are strongly attenuated at the soma (0.5-1 mV) and that the estimated neck resistance (mean 420 MΩ) is large enough to generate significant voltage compartmentalization. Nanopipettes can thus be used to electrically probe biological nanostructures.
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