Evidence map›Paper›PMID 27941863›Full record

ArticleNature microbiology2016

CozE is a member of the MreCD complex that directs cell elongation in Streptococcus pneumoniae.

Andrew K Fenton, Lamya El Mortaji, Derek T C Lau, David Z Rudner, Thomas G Bernhardt

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 87 citations in OpenAlex.

  1. A broadly conserved gram-positive lipoprotein regulates cell elongation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. ThebioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Curli-independent defense againstMicrobiology spectrum · 2025
    Article
  7. Article
  8. Article
  9. Characterization of MreCD inJournal of oral microbiology · 2025
    Article
  10. Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Transposon insertion site sequencing (TIS) of Pseudomonas aeruginosa.Journal of microbiology (Seoul, Korea) · 2021
    Article
  20. The bacterial tyrosine kinase system CpsBCD governs the length of capsule polymers.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew K FentonDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Lamya El MortajiDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Derek T C LauDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
David Z RudnerDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Thomas G BernhardtDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Harvard University · US

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI MEKALANOS, JOHN JOSEPH · 2014 to 2018
$25.2M
Peptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3M
Membrane Remodeling and Protein Trafficking in BacteriaR01GM073831 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RUDNER, DAVID Z · 2005 to 2014
$3.4M
A multidisciplinary approach to elucidating gene function in a model Gram-positivRC2GM092616 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2009 to 2010
$2.0M
NIAID NIH HHS R01 AI083365NIAID NIH HHS U19 AI109764NIGMS NIH HHS R01 GM073831NIGMS NIH HHS RC2 GM092616
6 · The paper itself

Abstract

Most bacterial cells are surrounded by a peptidoglycan cell wall that is essential for their integrity. The major synthases of this exoskeleton are called penicillin-binding proteins (PBPs)

Indexed as

Bacterial ProteinsCell WallDNA Transposable ElementsMutagenesis, InsertionalPeptidoglycanPeptidyl TransferasesSequence Analysis, DNAStreptococcus pneumoniaeBacterial ProteinsDNA Transposable ElementsPBP1a protein, Streptococcus pneumoniaePeptidoglycanPeptidyl Transferases

Identifiers

PMID27941863
PMCPMC5486215
OpenAlexW2564679034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.