ArticleScientific reports2016
In vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- A Redefined Protocol for Protein Corona Analysis on Graphene Oxide.ACS nanoscience Au · 2025Article
- From yield stress to elastic instabilities: Tuning the extensional behavior of elastoviscoplastic fluids.PNAS nexus · 2024Article
- Biocompatible adipose extracellular matrix and reduced graphene oxide nanocomposite for tissue engineering applications.Materials today. Bio · 2024Article
- [Immunogenic and toxic effects of graphene oxide nanoparticles in mouse skeletal muscles and human red blood cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Stabilization of Graphene Oxide Dispersion in Plasma-like Isotonic Solution Containing Aggregating Concentrations of Bivalent Cations.Pharmaceutics · 2023Article
- Differential Toxicity of Graphene Family Nanomaterials Concerning Morphology.Advances in experimental medicine and biology · 2022Article
- Graphene-Based Biomaterials for Bone Regenerative Engineering: A Comprehensive Review of the Field and Considerations Regarding Biocompatibility and Biodegradation.Advanced healthcare materials · 2021Review
- Recent Advances in Immunosafety and Nanoinformatics of Two-Dimensional Materials Applied to Nano-imaging.Frontiers in immunology · 2021Review
- Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?International journal of nanomedicine · 2020Review
- Synthesis, Characterization, and Toxicity Assessment of Pluronic F127-Functionalized Graphene Oxide on the Embryonic Development of Zebrafish (International journal of nanomedicine · 2020Article
- Evaluation of Graphene Oxide Induced Cellular Toxicity and Transcriptome Analysis in Human Embryonic Kidney Cells.Nanomaterials (Basel, Switzerland) · 2019Article
- Differential Cytotoxicity of Different Sizes of Graphene Oxide Nanoparticles in Leydig (TM3) and Sertoli (TM4) Cells.Nanomaterials (Basel, Switzerland) · 2019Article
- Differential Immunomodulatory Effect of Graphene Oxide and Vanillin-Functionalized Graphene Oxide Nanoparticles in Human Acute Monocytic Leukemia Cell Line (THP-1).International journal of molecular sciences · 2019Article
- 3D Printing of Thermoresponsive Polyisocyanide (PIC) Hydrogels as Bioink and Fugitive Material for Tissue Engineering.Polymers · 2018Article
- Main trends of immune effects triggered by nanomedicines in preclinical studies.International journal of nanomedicine · 2018Review
- Graphene and the Immune System: A Romance of Many Dimensions.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphene oxide (GO) has been a focus of research in the fields of electronics, energy, and biomedicine, including drug delivery. Thus, single- and multi-layered GO (SLGO and MLGO) have been produced and investigated. However, little information on their toxicity and biocompatibility is available. In the present study, we performed a comprehensive study of the size- and dose-dependent toxicity of GOs in the presence or absence of Pluronic F-127 on THP-1 cells by examining their viability, membrane integrity, levels of cytokine and ROS production, phagocytosis, and cytometric apoptosis. Moreover, as an extended study, a toxicity evaluation in the acute and chronic phases was performed in mice via intravenous injection of the materials. GOs exhibited dose- and size-dependent toxicity. Interestingly, SLGO induced ROS production to a lesser extent than MLGO. Cytometric analysis indicated that SLGO induced necrosis and apoptosis to a lesser degree than MLGO. In addition, cell damage and IL-1β production were influenced by phagocytosis. A histological animal study revealed that GOs of various sizes induced acute and chronic damage to the lung and kidney in the presence or absence of Pluronic F-127. These results will facilitate studies of GO prior to its biomedical application.
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