ArticleScientific reports2016
Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 169 citations in OpenAlex.
- Solvent-Directed Phase Control in Disulfide-Linked Metal-Organic Frameworks Revealed by Microcrystal Electron Diffraction.Precision chemistry · 2026Article
- Exploring Disulfide Bridge as a Tool to Improve Pioglitazone's Neuroprotective Potential: Toward the Development of Prolonged-Acting MAO-B/PPARγ Modulators.ChemMedChem · 2026Article
- Rapid differentiation of D/L-homocysteine, D/L-homocystine, and S-allyl-D/L-cysteine using ion mobility-mass spectrometry.Analytical and bioanalytical chemistry · 2026Article
- Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly.Redox report : communications in free radical research · 2025Article
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- Molecular and phenotypic insights into sulfur's role in enhancing tomato plant growth, stress tolerance, and productivity.Scientific reports · 2025Article
- Accurate structure prediction of cyclic peptides containing unnatural amino acids using HighFold3.Briefings in bioinformatics · 2025Article
- Size-Dependent Ultrafast UV Photochemistry of Aliphatic Disulfides in Solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Isoform switch of T-cell factor7L2 during mouse heart development.Journal of molecular and cellular cardiology plus · 2025Article
- Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus.The Biochemical journal · 2025Article
- Fisetin as a Blueprint for Senotherapeutic Agents - Elucidating Geroprotective and Senolytic Properties with Molecular Modeling.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Breath and Beyond: Advances in Nanomedicine for Oral and Intranasal Aerosol Drug Delivery.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Preferential binding of ADP-bound mitochondrial HSP70 to the nucleotide exchange factor GRPEL1 over GRPEL2.Protein science : a publication of the Protein Society · 2024Article
- Article
- Evolution of fungal tuberculosis necrotizing toxin (TNT) domain-containing enzymes reveals divergent adaptations to enhance NAD cleavage.Protein science : a publication of the Protein Society · 2024Article
- Simulation of gap junction formation reveals critical role of Cys disulfide redox state in connexin hemichannel docking.Cell communication and signaling : CCS · 2024Article
- Structural insights into the disulfide isomerase and chaperone activity of TrbB of the F plasmid type IV secretion system.Current research in structural biology · 2024Article
- Cell-Surface-Retained Peptide Additives for the Cytosolic Delivery of Functional Proteins.Journal of the American Chemical Society · 2023Article
- Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disulfide bonds play a key role in stabilizing protein structures, with disruption strongly associated with loss of protein function and activity. Previous data have suggested that disulfides show only modest reactivity with oxidants. In the current study, we report kinetic data indicating that selected disulfides react extremely rapidly, with a variation of 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.