ArticleScientific reports2016
MHC-dependent mate choice is linked to a trace-amine-associated receptor gene in a mammal.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- MHC-DRB heterozygosity may increase subordinate but not alpha male siring success in white-faced capuchin monkeys (Cebus imitator).Primates; journal of primatology · 2026Article
- Natural variability of trace-amine associated receptors in wild meerkats.Frontiers in zoology · 2025Article
- Female-mediated selective sperm activation may remodel major histocompatibility complex-based mate choice decisions in humans.Heredity · 2025Article
- Adaptation in the Alleyways: Candidate Genes Under Potential Selection in Urban Coyotes.Genome biology and evolution · 2025Article
- No evidence for a role of MHC class II genotype in the chemical encoding of heterozygosity and relatedness in Antarctic fur seals.Proceedings. Biological sciences · 2024Article
- Genomic consequences of a century of inbreeding and isolation in the Danish wild boar population.Evolutionary applications · 2022Article
- The niche of One Health approaches in Lassa fever surveillance and control.Annals of clinical microbiology and antimicrobials · 2021Review
- Comparative genomic analyses illuminate the distinct evolution of megabats within Chiroptera.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- TAAR Agonists.Cellular and molecular neurobiology · 2020Review
- Expressed Vomeronasal Type-1 Receptors (V1rs) in Bats Uncover Conserved Sequences Underlying Social Chemical Signaling.Genome biology and evolution · 2019Article
- Can extreme MHC class I diversity be a feature of a wide geographic range? The example of Seba's short-tailed bat (Carollia perspicillata).Immunogenetics · 2019Article
- MHC class I diversity predicts non-random mating in Chinese alligators (Alligator sinensis).Heredity · 2019Article
- Challenges of next-generation sequencing in conservation management: Insights from long-term monitoring of corridor effects on the genetic diversity of mouse lemurs in a fragmented landscape.Evolutionary applications · 2019Article
- The best smellers make the best choosers: mate choice is affected by female chemosensory receptor gene diversity in a mammal.Proceedings. Biological sciences · 2018Article
- Male Scent Gland Signals Mating Status in Greater Spear-Nosed Bats, Phyllostomus hastatus.Journal of chemical ecology · 2018Article
- A predicted interaction between odour pleasantness and intensity provides evidence for major histocompatibility complex social signalling in women.Proceedings. Biological sciences · 2018Article
- How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest.Frontiers in pharmacology · 2018Article
- Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders.Frontiers in pharmacology · 2018Article
- Vomeronasal and Olfactory Structures in Bats Revealed by DiceCT Clarify Genetic Evidence of Function.Frontiers in neuroanatomy · 2018Article
- Bat songs as acoustic beacons - male territorial songs attract dispersing females.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) genes play a pivotal role in vertebrate self/nonself recognition, parasite resistance and life history decisions. In evolutionary terms, the MHC's exceptional diversity is likely maintained by sexual and pathogen-driven selection. Even though MHC-dependent mating preferences have been confirmed for many species, the sensory and genetic mechanisms underlying mate recognition remain cryptic. Since olfaction is crucial for social communication in vertebrates, variation in chemosensory receptor genes could explain MHC-dependent mating patterns. Here, we investigated whether female mate choice is based on MHC alleles and linked to variation in chemosensory trace amine-associated receptors (TAARs) in the greater sac-winged bat (Saccopteryx bilineata). We sequenced several MHC and TAAR genes and related their variation to mating and paternity data. We found strong evidence for MHC class I-dependent female choice for genetically diverse and dissimilar males. We also detected a significant interaction between mate choice and the female TAAR3 genotype, with TAAR3-heterozygous females being more likely to choose MHC-diverse males. These results suggest that TAARs and olfactory cues may be key mediators in mammalian MHC-dependent mate choice. Our study may help identify the ligands involved in the chemical communication between potential mates.
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