Evidence map›Paper›PMID 27941775›Full record

Trial reportBone marrow transplantation2017

Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue.

S E Ghazikhanian, C S Dorfman, T J Somers, M L O'Sullivan, H M Fisher, S N Edmond, A A Wren, S A Kelleher, K A Rowe Nichols, N Chao and 1 more

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in Bone marrow transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Short-Term Impact of Hematopoietic Stem Cell Transplantation on Depressive Behavior, Cognition and Quality of Life in Leukemia Patients.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Patient-reported cognitive function among hematopoietic stem cell transplant and cellular therapy patients: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

S E GhazikhanianPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
C S DorfmanPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
T J SomersPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
M L O'SullivanPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
H M FisherDepartment of Psychology, University of Miami, Coral Gables, FL, USA.
S N EdmondHealth Psychology, VA Connecticut Healthcare System, New Haven, CT, USA.
A A WrenDepartment of Anesthesiology, Perioperative and Pain Medicine, Standford University Medical Center, Palo Alto, CA, USA.
S A KelleherPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
K A Rowe NicholsPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
N ChaoPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
R A ShelbyPsychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.

Funding

Improving Adherence to Recommended Surveillance in Breast Cancer SurvivorsK07CA138767 · NCI · DUKE UNIVERSITY · PI SHELBY, REBECCA A · 2010 to 2014
$788k
NCI NIH HHS K07 CA138767
6 · The paper itself

Abstract

Cognitive problems are a significant, persistent concern for patients undergoing hematopoietic stem cell transplant (HSCT). Sleep is important for many cognitive tasks; however, the relationship between sleep and cognitive problems for HSCT patients is unknown. This study examined the relationship between sleep and cognitive problems for HSCT patients from pre to post transplant. Patients undergoing HSCT (N=138) completed questionnaires at pre-transplant and during the 12 months following transplant. Questionnaires assessed sleep and cognitive problems as well as commonly co-occurring symptoms: depressive symptoms, fatigue and pain. Post hoc analyses examined the relationship of specific sleep problems with cognitive problems. Sleep problems covaried with cognitive problems even after controlling for depressive symptoms, fatigue and pain. Depressive symptoms and fatigue were also uniquely related to cognitive problems. Post hoc analyses suggest that sleep somnolence, shortness of breath, snoring and perceptions of inadequate sleep may contribute to the association found between sleep and cognitive problems. Findings suggest that sleep problems are associated with and may contribute to cognitive problems for HSCT patients. However, sleep problems are rarely screened for or discussed during clinic visits. Assessing and treating specific sleep problems in addition to depressive symptoms and fatigue may have implications for improving cognitive problems for HSCT patients.

Indexed as

Cognitive DysfunctionDepressionFatigueHematopoietic Stem Cell TransplantationSleep Wake DisordersAdultAgedAged, 80 and overAllograftsAutograftsFemaleHumansMaleMiddle Aged

Identifiers

PMID27941775
PMCPMC5288285

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.