ArticleClinical nuclear medicine2017
Added Value of Combined Semi-Quantitative and Visual [123I]FP-CIT SPECT Analyses for the Diagnosis of Dementia With Lewy Bodies.
Article in Clinical nuclear medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Diagnostic performance of molecular imaging methods in predicting the progression from mild cognitive impairment to dementia: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2024Pooled it
- The diagnostic performance of functional dopaminergic scintigraphic imaging in the diagnosis of dementia with Lewy bodies: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2023Pooled it
- Diagnostic accuracy of DAT-SPECT and MIBG scintigraphy for dementia with Lewy bodies: an updated systematic review and Bayesian latent class model meta-analysis.European journal of nuclear medicine and molecular imaging · 2020Pooled it
- Evaluating dopamine transporter imaging as an enrichment biomarker in a phase 2 Parkinson's disease trial.BMC neurology · 2021Trial
- Semiquantitative [¹²³I]FP-CIT SPECT metrics combined with machine learning improve clinical differentiation of Parkinson's disease and atypical parkinsonian syndrome.European journal of nuclear medicine and molecular imaging · 2026Article
- Imaging tau burden in dementia with Lewy bodies using [Neurobiology of aging · 2021Article
- A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single-photon emission computed tomography.Annals of nuclear medicine · 2021Article
- Feeling of presence in dementia with Lewy bodies is related to reduced left frontoparietal metabolism.Brain imaging and behavior · 2020Article
- A Novel Automatic Approach for Calculation of the Specific Binding Ratio in [I-123]FP-CIT SPECT.Diagnostics (Basel, Switzerland) · 2020Article
- Single-siteEuropean journal of hybrid imaging · 2020Article
- Review
- Impact of the cerebrospinal fluid-mask algorithm on the diagnostic performance ofEJNMMI research · 2019Article
- Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies.Psychological medicine · 2019Article
- Dementia with Lewy bodies: an update and outlook.Molecular neurodegeneration · 2019Review
- Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2018Article
- Semi-quantitative dopamine transporter standardized uptake value in comparison with conventional specific binding ratio in [123I] FP-CIT single-photon emission computed tomography (DaTscan).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Clinical imaging in dementia with Lewy bodies.Evidence-based mental health · 2018Review
- Response to the letter to the editor of Nicolas Nicastro et al.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- The added value of combined visual and semi-quantitative assessment forNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the reportTo assess the validity of a semi-quantitative I-FP-CIT SPECT method, compared to the commonly used visual analysis, in patients with probable dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We also studied DLB specific uptake impairment pattern and correlation of uptake in the presence or absence of parkinsonism. MATERIALS AND
methodsAmong 1202 scans performed at our center from 2003 to 2015, we identified 93 subjects with probable DLB (mean age 76.9 ± 6.8 years, 37% women) and 18 with AD (mean age 76.9 ± 8.1 years, 50% women). Independent visual and semi-quantitative assessments based on previously established on-site reference values (including volumes-of-interest uptake, caudate-to-putamen ratio and striatal asymmetry index) were performed and compared between both groups.
resultsVisual staging was considered abnormal in 96.8% of DLB patients, whereas 97.8% of subjects had an abnormal semi-quantitative assessment. Combining both methods yielded a 100% sensitivity. Patients with DLB exhibited a more pronounced impairment of putaminal uptake when associated with parkinsonism, whereas a more diffuse pattern and significantly higher uptake values were observed in the subgroup of DLB patients without parkinsonism (resp. striatal uptake 1.61 ± 0.66 vs. 2.28 ± 0.52, P = 0.01). A minority of AD subjects show minimal alterations of presynaptic dopaminergic transport (striatal uptake 3.07 ± 0.41), values being always significantly higher than those from DLB patients, irrespective of the presence of parkinsonism (P < 0.0001) or not (P = 0.002).
conclusionsAdditional use of semi-quantitative analysis allows a higher discrimination of DLB from AD and demonstrates a specific pattern of degeneration in DLB patients according to their motor phenotype.
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