ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2016
Peroxisome biogenesis and human peroxisome-deficiency disorders.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Exploring the Role of Peroxisome-Related Processes and Key Marker Genes in Sepsis: Insights Into Immune Dynamics and Therapeutic Potential.Journal of inflammation research · 2025Article
- PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer.Digestive diseases and sciences · 2024Article
- The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10.Autophagy · 2023Article
- Protein import into peroxisomes occurs through a nuclear pore-like phase.Science (New York, N.Y.) · 2022Article
- PEX5 translocation into and out of peroxisomes drives matrix protein import.Molecular cell · 2022Article
- Genotype-phenotype correlations and disease mechanisms in PEX13-related Zellweger spectrum disorders.Orphanet journal of rare diseases · 2022Article
- Peroxisome function relies on organelle-associated mRNA translation.Science advances · 2022Article
- Control of mitochondrial dynamics and apoptotic pathways by peroxisomes.Frontiers in cell and developmental biology · 2022Review
- Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Article
- Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment.Neuropathology and applied neurobiology · 2021Article
- Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins.Frontiers in cell and developmental biology · 2021Article
- A Novel Mutation in PEX11β Gene.Iranian journal of child neurology · 2021Article
- Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.The EMBO journal · 2020Article
- Accurate and live peroxisome biogenesis evaluation achieved by lentiviral expression of a green fluorescent protein fused to a peroxisome targeting signal 1.Histochemistry and cell biology · 2020Article
- Peroxisome protein import recapitulated inThe Journal of cell biology · 2019Article
- A newly identified mutation in theCold Spring Harbor molecular case studies · 2019Article
- Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.Life science alliance · 2018Article
- Article
- A clinical case of Zellweger syndrome in a patient with a previous history of ocular medulloepithelioma.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroxisome is a single-membrane-bounded ubiquitous organelle containing a hundred different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. To investigate peroxisome biogenesis and human peroxisome biogenesis disorders (PBDs) including Zellweger syndrome, more than a dozen different complementation groups of Chinese hamster ovary (CHO) cell mutants impaired in peroxisome biogenesis are isolated as a model experimental system. By taking advantage of rapid functional complementation assay of the CHO cell mutants, successful cloning of PEX genes encoding peroxins required for peroxisome assembly invaluably contributed to the accomplishment of cloning of pathogenic genes responsible for PBDs. Peroxins are divided into three groups: 1) peroxins including Pex3p, Pex16p and Pex19p, are responsible for peroxisome membrane biogenesis via Pex19p- and Pex3p-dependent class I and Pex19p- and Pex16p-dependent class II pathways; 2) peroxins that function in matrix protein import; 3) those such as Pex11pβ are involved in peroxisome division where DLP1, Mff, and Fis1 coordinately function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.