ArticleThe Journal of reproduction and development2017
Effects of downregulating TEAD4 transcripts by RNA interference on early development of bovine embryos.
Article in The Journal of reproduction and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Lineage Differentiation Markers as a Proxy for Embryo Viability in Farm Ungulates.Frontiers in veterinary science · 2021Pooled it
- The role of TEAD4 in trophectoderm commitment and development is not conserved in non-rodent mammals.Development (Cambridge, England) · 2024Article
- Developmental Hurdles That Can Compromise Pregnancy during the First Month of Gestation in Cattle.Animals : an open access journal from MDPI · 2023Review
- Early Cell Specification in Mammalian Fertilized and Somatic Cell Nuclear Transfer Embryos.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling.Reproduction (Cambridge, England) · 2022Review
- Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo.Cell and tissue research · 2021Review
- Roles of cell differentiation factors in preimplantation development of domestic animals.The Journal of reproduction and development · 2021Review
- Review
- Cell differentiation events in pre-implantation mouse and bovine embryos.Animal reproduction · 2021Review
- Characterization of DNA Methylation Patterns and Mining of Epigenetic Markers During Genomic Reprogramming in SCNT Embryos.Frontiers in cell and developmental biology · 2020Article
- The necessity of TEAD4 for early development and gene expression involved in differentiation in porcine embryos.The Journal of reproduction and development · 2019Article
- Review
- Role of yes-associated protein 1, angiomotin, and mitogen-activated kinase kinase 1/2 in development of the bovine blastocyst.Biology of reproduction · 2018Article
- Comparative aspects of early lineage specification events in mammalian embryos - insights from reverse genetics studies.Cell cycle (Georgetown, Tex.) · 2018Article
- Single-cell gene expression of the bovine blastocyst.Reproduction (Cambridge, England) · 2017Article
- Consequences of endogenous and exogenous WNT signaling for development of the preimplantation bovine embryo.Biology of reproduction · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription factor TEA domain family transcription factor 4 (Tead4) is one of the key factors involved in the differentiation of the trophectoderm (TE) in murine embryos. However, knowledge on the roles of TEAD4 in preimplantation development during bovine embryos is currently limited. This study examined the transcript and protein expression patterns of TEAD4 and attempted to elucidate the functions of TEAD4 during bovine preimplantation development using RNA interference. TEAD4 mRNA was found to be upregulated between the 16-cell and morula stages, and nuclear localization of the TEAD4 protein was detected at the morula stage, as well as in subsequent developmental stages. TEAD4 downregulation did not affect embryonic development until the blastocyst stage, and TEAD4-downregulated embryos were capable of forming the TE under both 5% and 21% O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.