ArticleAnnals of botany2017
The Fusarium crown rot pathogen Fusarium pseudograminearum triggers a suite of transcriptional and metabolic changes in bread wheat (Triticum aestivum L.).
Article in Annals of botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Tryptophan metabolism and plant health: mechanisms of action and application prospects.Frontiers in plant science · 2026Pooled it
- Identification of Key Gene Network Modules and Hub Genes Associated with Wheat Response to Biotic Stress Using Combined Microarray Meta-analysis and WGCN Analysis.Molecular biotechnology · 2023Pooled it
- Biosynthesis of pathogen-induced hydroxylated tryptamine derivatives in barley.Plant physiology · 2026Article
- A Dual-Role Transcription Factor FpCys3 Couples Glucose Sensing to Methionine Biosynthesis and Virulence in Fusarium pseudograminearum.Plant, cell & environment · 2026Article
- Evaluation on Fusarium crown rot resistance and agronomic traits of wheat near-isogenic lines.BMC plant biology · 2026Article
- Phenotypic and comparative transcriptomic analyses of resistant and susceptible germplasm reveal the putative resistance mechanisms of wheat to fusarium crown rot.BMC genomics · 2025Article
- The TOX2 Gene Is Responsible for Conidiation and Full Virulence inCurrent issues in molecular biology · 2025Article
- Crown rot in wheat: pathogen biology, host responses, and management strategies.Stress biology · 2025Review
- TaHSP18.6 and TaSRT1 interact to confer resistance toProceedings of the National Academy of Sciences of the United States of America · 2025Article
- A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat.Nature communications · 2025Article
- Velvet Family Protein FpVelB Affects Virulence in Association with Secondary Metabolism inCells · 2024Article
- A novel QTL conferring Fusarium crown rot resistance on chromosome 2A in a wheat EMS mutant.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Grass lignin: biosynthesis, biological roles, and industrial applications.Frontiers in plant science · 2024Review
- Comparative analysis of Fusarium crown rot resistance in synthetic hexaploid wheats and their parental genotypes.BMC genomics · 2023Article
- A Novel Wall-Associated Kinase TaWAK-5D600 Positively Participates in Defense against Sharp Eyespot andInternational journal of molecular sciences · 2023Article
- The global regulator FpLaeB is required for the regulation of growth, development, and virulence inFrontiers in plant science · 2023Article
- Comprehensive analysis of pathogen-responsive wheat NAC transcription factors: new candidates for crop improvement.G3 (Bethesda, Md.) · 2022Article
- 3-keto-DON, but Not 3-International journal of molecular sciences · 2022Article
- Pathogen-induced biosynthetic pathways encode defense-related molecules in bread wheat.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- BdGUCD1 and Cyclic GMP Are Required for Responses ofInternational journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Fusarium crown rot caused by the fungal pathogen Fusarium pseudograminearum is a disease of wheat and barley, bearing significant economic cost. Efforts to develop effective resistance to this disease have been hampered by the quantitative nature of resistance and a lack of understanding of the factors associated with resistance and susceptibility. Here, we aimed to dissect transcriptional responses triggered in wheat by F. pseudograminearum infection. Methods: We used an RNA-seq approach to analyse host responses during a compatible interaction and identified >2700 wheat genes differentially regulated after inoculation with F. pseudograminearum . The production of a few key metabolites and plant hormones in the host during the interaction was also analysed. Key Results: Analysis of gene ontology enrichment showed that a disproportionate number of genes involved in primary and secondary metabolism, signalling and transport were differentially expressed in infected seedlings. A number of genes encoding pathogen-responsive uridine-diphosphate glycosyltransferases (UGTs) potentially involved in detoxification of the Fusarium mycotoxin deoxynivalenol (DON) were differentially expressed. Using a F. pseudograminearum DON-non-producing mutant, DON was shown to play an important role in virulence during Fusarium crown rot. An over-representation of genes involved in the phenylalanine, tryptophan and tyrosine biosynthesis pathways was observed. This was confirmed through metabolite analyses that demonstrated tryptamine and serotonin levels are induced after F. pseudograminearum inoculation. Conclusions: Overall, the observed host response in bread wheat to F. pseudograminearum during early infection exhibited enrichment of processes related to pathogen perception, defence signalling, transport and metabolism and deployment of chemical and enzymatic defences. Additional functional analyses of candidate genes should reveal their roles in disease resistance or susceptibility. Better understanding of host responses contributing to resistance and/or susceptibility will aid the development of future disease improvement strategies against this important plant pathogen.
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