ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017
Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes.
Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Extracellular matrix stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids.Nature communications · 2026Article
- A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease.Advances in respiratory medicine · 2025Review
- Common genetic variation influencing the human lung imaging phenotypes.Nature communications · 2025Article
- Endobronchial optical coherence tomography helps to estimate the cartilage damage of the central airway in TBTB patients.Frontiers in cellular and infection microbiology · 2023Article
- Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.Nature communications · 2022Article
- Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies.Development (Cambridge, England) · 2021Article
- SOX9 inactivation affects the proliferation and differentiation of human lung organoids.Stem cell research & therapy · 2021Article
- Tumor Necrosis Factor Alpha Signaling and Organogenesis.Frontiers in cell and developmental biology · 2021Review
- Mesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Review
- Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus.Nature communications · 2018Article
- Retinoic acid regulates avian lung branching through a molecular network.Cellular and molecular life sciences : CMLS · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The signaling cross talk between the tracheal mesenchyme and epithelium has not been researched extensively, leaving a substantial gap of knowledge in the mechanisms dictating embryonic development of the proximal airways by the adjacent mesenchyme. Recently, we reported that embryos lacking mesenchymal expression of Sox9 did not develop tracheal cartilage rings and showed aberrant differentiation of the tracheal epithelium. Here, we propose that tracheal cartilage provides local inductive signals responsible for the proper differentiation, metabolism, and inflammatory status regulation of the tracheal epithelium. The tracheal epithelium of mesenchyme-specific Sox9
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Registered trials
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