Evidence map›Paper›PMID 27941025›Full record

ArticleThe Journal of biological chemistry2017

A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury.

Taiji Ishii, Takehiko Ueyama, Michiko Shigyo, Masaaki Kohta, Takeshi Kondoh, Tomoharu Kuboyama, Tatsuya Uebi, Takeshi Hamada, David H Gutmann, Atsu Aiba and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  8. The role of astrocytes in neuropathic pain.Frontiers in molecular neuroscience · 2022
    Review
  9. Article
  10. The far-reaching HAND of cART: cART effects on astrocytes.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  11. Review
  12. Article
  13. Article
  14. An update on reactive astrocytes in chronic pain.Journal of neuroinflammation · 2019
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Taiji IshiiFrom the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan.
Takehiko UeyamaFrom the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan, tueyama@kobe-u.ac.jp.ORCID 0000-0002-5647-3937
Michiko Shigyothe Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Masaaki Kohtathe Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Takeshi Kondohthe Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Tomoharu Kuboyamathe Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Tatsuya UebiFrom the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan.
Takeshi HamadaFrom the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan.
David H Gutmannthe Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, and.
Atsu Aibathe Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Eiji Kohmurathe Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Chihiro Tohdathe Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Naoaki SaitoFrom the Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657-8501, Japan, naosaito@kobe-u.ac.jp.
Kobe University · JPUniversity of Toyama · JPThe University of Tokyo · JPWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrogliosis (i.e. glial scar), which is comprised primarily of proliferated astrocytes at the lesion site and migrated astrocytes from neighboring regions, is one of the key reactions in determining outcomes after CNS injury. In an effort to identify potential molecules/pathways that regulate astrogliosis, we sought to determine whether Rac/Rac-mediated signaling in astrocytes represents a novel candidate for therapeutic intervention following CNS injury. For these studies, we generated mice with Rac1 deletion under the control of the GFAP (glial fibrillary acidic protein) promoter (GFAP-Cre;Rac1

Indexed as

AnimalsAstrocytesGliosisInterleukin-1betaMiceMice, KnockoutNeuropeptidesPeptide Termination Factorsrac1 GTP-Binding ProteinSpinal Cord InjuriesIL1B protein, mouseInterleukin-1betaNeuropeptidespeptide-chain-release factor 3Peptide Termination Factorsrac1 GTP-Binding ProteinRac1 protein, mouseastrocytecell cyclecell migrationcell proliferationCNS injuryglial cellGSPT1inflammationmouseRac (Rac GTPase)

Identifiers

PMID27941025
PMCPMC5270470
OpenAlexW2560576175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.