ArticleScience (New York, N.Y.)2016
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish.
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 203 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
203 citing papers in PubMed.
- Harnessing macrogenomics to study changing marine ecosystems under global climate change.Proceedings. Biological sciences · 2026Review
- Evidence from three taxonomically distinct species for a non-AhR mechanism of developmental neurotoxicity of an environmentally derived mixture of polycyclic aromatic hydrocarbons.bioRxiv : the preprint server for biology · 2026Article
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Predictions From Evolutionary Theory for Urban Environments.Evolutionary applications · 2026Article
- Discovery and Evaluation of Cadmium-Adapted Daphnia pulex Genotypes in a Region of Historical Mining Reveals Adaptation Protects the Germline From Cadmium-Induced Mutations.Molecular ecology · 2026Article
- Signatures of Radiation-Induced Stress and Putative Selection on Immune Targets in Chornobyl Wolves.Molecular ecology · 2026Article
- Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Rapid urbanization reduces genetic diversity and increases genetic differentiation of a lynx spider Oxyopes sertatus in central Taiwan.Scientific reports · 2026Article
- Digitaria genome analyses indicate introgression may drive local adaptation and herbicide resistance.Nature communications · 2026Article
- Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?Diabetologia · 2026Review
- Aip mutation leads to significant alterations in gene expression, altered sensitivity to Ahr ligands, and early lethality in zebrafish.Frontiers in toxicology · 2026Article
- Constructing Petroleum-Derived Aryl Hydrocarbon Receptor Related Toxic Source Profiles via Effect-Directed Analysis.Environment & health (Washington, D.C.) · 2025Article
- Genomic identification of direct seeding and evolutionary lineages by combining heterogeneous genomic resources.BMC biology · 2025Article
- Identifying the Degree of Gene Reuse During Repeated Adaptation.Molecular ecology · 2025Review
- Whole-Genome Duplication Reshapes Adaptation: Autotetraploid Arabidopsis arenosa Leverages its High Genetic Variation to Compensate for Selection Constraints.Molecular biology and evolution · 2025Article
- Ecological and Mutation-Order Speciation in Senecio.Molecular ecology · 2025Article
- Alternative Splicing and Gene Expression Variation Underlie Population and Life History Differences in an Amphibian.Ecology and evolution · 2025Article
- Strong but diffuse genetic divergence underlies differentiation in an incipient species of marine stickleback.bioRxiv : the preprint server for biology · 2025Article
- Early Life PBDE Flame Retardant Exposures Cause Neurobehavioral Alterations in Fish That Persist into Adulthood and Vary by Sex and Route of Exposure.Environmental science & technology · 2025Article
143 more citing papers are in PubMed but not listed here.
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12 authors.
Funding
Abstract
Atlantic killifish populations have rapidly adapted to normally lethal levels of pollution in four urban estuaries. Through analysis of 384 whole killifish genome sequences and comparative transcriptomics in four pairs of sensitive and tolerant populations, we identify the aryl hydrocarbon receptor-based signaling pathway as a shared target of selection. This suggests evolutionary constraint on adaptive solutions to complex toxicant mixtures at each site. However, distinct molecular variants apparently contribute to adaptive pathway modification among tolerant populations. Selection also targets other toxicity-mediating genes and genes of connected signaling pathways; this indicates complex tolerance phenotypes and potentially compensatory adaptations. Molecular changes are consistent with selection on standing genetic variation. In killifish, high nucleotide diversity has likely been a crucial substrate for selective sweeps to propel rapid adaptation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.