ArticleJournal of clinical pathology1989
Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen.
Article in Journal of clinical pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- CD43 expressed in Sertoli, Leydig and germ cells inhibits testicular function and represents a potential target to treat male infertility or effect male contraception.Reproductive biology and endocrinology : RB&E · 2025Article
- Patient-derived antibody recognizes a unique CD43 epitope expressed on all AML and has antileukemia activity in mice.Blood advances · 2017Article
- Galectin-1 regulates tissue exit of specific dendritic cell populations.The Journal of biological chemistry · 2015Article
- Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual immunotoxin.British journal of cancer · 2001Article
- CNA.42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cells.The American journal of pathology · 1997Article
- Article
- A new CD43 monoclonal antibody induces homotypic aggregation of human leucocytes through a CD11a/CD18-dependent and -independent mechanism.Immunology · 1993Article
- CD43 expression in B cell lymphoma.Journal of clinical pathology · 1992Article
- T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome.The Journal of experimental medicine · 1992Article
- Non-isotopic in situ hybridisation and immunophenotyping of infected cells in the investigation of human fetal parvovirus infection.Journal of clinical pathology · 1992Article
- Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin).Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomas.British journal of cancer · 1991Article
- Immunohistological diagnosis of "plasmacytoid T cell lymphoma" in paraffin wax sections.Journal of clinical pathology · 1991Article
- Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.Journal of clinical pathology · 1991Article
- Human immunodeficiency virus type 1-infected individuals make autoantibodies that bind to CD43 on normal thymic lymphocytes.The Journal of experimental medicine · 1990Article
- Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.The American journal of pathology · 1990Article
- Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen.Journal of clinical pathology · 1989Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Three monoclonal antibodies MT1, L60 (Leu-22), and DF-T1, were reported independently as recognising human T cells in routinely processed, paraffin wax embedded tissue. The present study was performed to compare these three reagents in terms of their immunocytochemical reactions and target molecule(s). On Western blotting of white cell extracts the three antibodies reacted with antigens of the same molecular weight (range 110-160 kilodaltons). Furthermore, their immunocytochemical reactivity with normal human cells, as analysed by two-colour flow cytometry, was essentially identical (labelling of monocytes, most T lymphocytes, and weak reactions with some B cells), and the antibodies gave closely similar reactions on 54 white cell derived neoplasms. To identify the target antigen for these three reagents, antibodies from the Third International Workshop on Leucocyte Antigens were reviewed and it was shown that the Western blotting and immunocytochemical reactions of MT1, L60 (Leu-22), and DF-T1 were identical with those of the reagents which defined the CD43 antigen (also known as leucosialin or sialophorin). Furthermore, all these antibodies reacted with cells transfected with a cDNA clone encoding CD43. It is concluded that antibodies MT1, L60 (Leu-22), and DF-T1 all recognise the heavily glycosylated myeloid/lymphoid associated CD43 antigen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.