Trial reportPediatrics2016
Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function.
Trial report in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis.Scientific reports · 2021Pooled it
- Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Effects of iron intake on neurobehavioural outcomes in African children: a systematic review and meta-analysis of randomised controlled trials.Wellcome open research · 2021Pooled it
- Beyond the Mind-Serum Trace Element Levels in Schizophrenic Patients: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- The Role of Iron in Brain Development: A Systematic Review.Nutrients · 2020Pooled it
- A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment.European journal of clinical nutrition · 2019Pooled it
- Measuring neurodevelopment in iron-deficient children in sub-Saharan Africa: A systematic review of evidence and gaps.Global epidemiology · 2026Article
- The influence of maternal anemia on neonatal neurodevelopment: a systematic review and meta-analysis.Asian biomedicine : research, reviews and news · 2026Article
- Prenatal Hemoglobin Concentration and Long-Term Child Neurocognitive Development.The American journal of tropical medicine and hygiene · 2025Article
- Minerals and Human Health: From Deficiency to Toxicity.Nutrients · 2025Review
- Iron deficiency anemia during pregnancy and maternal and neonatal health outcomes: A prospective study, Spain, 2021-2022.Heliyon · 2025Article
- Effects of prenatal iron deficiency on neurological development and related disorders in offspring.Frontiers in nutrition · 2025Review
- Associations between the Strengths and Difficulties Questionnaire (SDQ) and Tests of Variables of Attention (TOVA) in rural school-aged children in Benin Africa.Global mental health (Cambridge, England) · 2025Article
- Association between maternal haemoglobin status during pregnancy and children's mental and psychomotor development at 18 months of age: Evidence from rural Bangladesh.Global health action · 2024Article
- A district-level geospatial analysis of anaemia prevalence among rural men in India, 2019-21.International journal for equity in health · 2024Article
- Gender-specific association between serum ferritin and neurodevelopment in infants aged 6 to 12 months.Scientific reports · 2023Article
- Iron Metabolism and Ferroptosis in Physiological and Pathological Pregnancy.International journal of molecular sciences · 2022Review
- Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy.International journal of molecular sciences · 2022Review
- Low Hemoglobin Levels Are Associated with Reduced Psychomotor and Language Abilities in Young Ugandan Children.Nutrients · 2022Article
- Diagnosis of children with attention-deficit/hyperactivity disorder (ADHD) comorbid autistic traits (ATs) by applying quantitative magnetic resonance imaging techniques.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveTo investigate the impact of prenatal maternal iron deficiency (ID) on cord blood serum ferritin (CBSF) concentration and infant cognitive and motor development.
methodsOur prospective cohort study included 636 mother-singleton child pairs from 828 eligible pregnant women who were enrolled during their first antenatal care (ANC) visit in Allada, Benin, into a clinical trial comparing the efficacy of mefloquine and sulfadoxine-pyrimethamine. Venous blood samples of women were assessed for ferritin and hemoglobin concentrations at the first and second ANC visits (occurring at least 1-month apart) and at delivery. Women were prescribed daily iron and folic acid supplements throughout pregnancy. Hematologic examinations were repeated for cord blood at birth. At age 1 year, cognitive and motor functions of children were assessed by using the Mullen Scales of Early Learning.
resultsThe prevalence of prenatal ID at first and second ANC visits, and at delivery was 30.5%, 34.0%, and 28.4%, respectively. CBSF concentrations were similar between ID and non-ID pregnant women. Neither prenatal ID nor CBSF concentration was associated with poor cognitive or gross motor function of children at age 1 year. CBSF concentrations were lower among mothers who had ID anemia (IDA) at delivery compared with non-IDA pregnant women (adjusted mean difference: -0.2 [95% confidence interval: -0.4 to -0.0]).
conclusionsIn a malaria-endemic region, ID in pregnancy in the context of iron supplementation is neither associated with CBSF concentration nor with infant cognitive and motor development. Prenatal IDA around the time of delivery is associated with lower CBSF concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.