Evidence map›Paper›PMID 27940662›Full record

ArticlePhysiological reports2016

Deep-targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans.

Linda S Pescatello, Elizabeth D Schifano, Garrett I Ash, Gregory A Panza, Lauren Lamberti, Ming-Hui Chen, Ved Deshpande, Amanda Zaleski, Paulo Farinatti, Beth A Taylor and 1 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Linda S PescatelloDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut Linda.Pescatello@uconn.edu.
Elizabeth D SchifanoDepartment of Statistics, University of Connecticut, Storrs, Connecticut.
Garrett I AshSchool of Nursing, Yale University, New Haven, Connecticut.
Gregory A PanzaDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Lauren LambertiDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Storrs, Connecticut.
Ved DeshpandeDepartment of Statistics, University of Connecticut, Storrs, Connecticut.
Amanda ZaleskiDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Paulo FarinattiDepartment of Physical Activity Sciences, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Beth A TaylorDepartment of Kinesiology, University of Connecticut, Storrs, Connecticut.
Paul D ThompsonDepartment of Preventive Cardiology, Hartford Hospital, Hartford, Connecticut.
University of Connecticut · USHartford Hospital · USUniversidade do Estado do Rio de Janeiro · BRYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We found variants from the Angiotensinogen-Converting Enzyme (ACE), Angiotensin Type 1 Receptor (AGTR1), Aldosterone Synthase (CYP11B2), and Adducin (ADD1) genes exhibited intensity-dependent associations with the ambulatory blood pressure (BP) response following acute exercise, or postexercise hypotension (PEH). In a validation cohort, we sequenced exons from these genes for their associations with PEH Obese (30.9 ± 3.6 kg m

Indexed as

AdducinsAdultBlack or African AmericanBlood PressureBlood Pressure Monitoring, AmbulatoryCalmodulin-Binding ProteinsCytochrome P-450 CYP11B2Exercise TestExercise ToleranceExonsFemaleHumansHypertensionKidneyMaleMiddle AgedAdducinsCalmodulin-Binding ProteinsCytochrome P-450 CYP11B2Blood pressureexercisehypertensionpolymorphism

Identifiers

PMID27940662
PMCPMC5064144
OpenAlexW2529893480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.