SynthesisPediatrics2017
Oxygen Saturation Targets in Preterm Infants and Outcomes at 18-24 Months: A Systematic Review.
Synthesis in Pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Automated versus manual control of inspired oxygen to target oxygen saturation in preterm infants: a systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2018Pooled it
- Effects of targeting lower versus higher arterial oxygen saturations on death or disability in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Oxygen saturation targeting by pulse oximetry in the extremely low gestational age neonate: a quixotic quest.Current opinion in pediatrics · 2017Pooled it
- Article
- Comparing infant pain and stress during retinopathy of prematurity screening using ophthalmoscopy and non-contact imaging.Scientific reports · 2025Article
- Impact of cessation of caffeine citrate therapy on intermittent hypoxemia patterns among preterm infants born before 34 weeks.Frontiers in pediatrics · 2025Article
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Temporal Dynamics of Oxidative Stress and Inflammation in Bronchopulmonary Dysplasia.International journal of molecular sciences · 2024Review
- Heart Rate and Pulse Oximetry Dynamics in the First Week after Birth in Neonatal Intensive Care Unit Patients and the Risk of Cerebral Palsy.American journal of perinatology · 2024Article
- Oxygen Targets in Neonatal Pulmonary Hypertension: Individualized, "Precision-Medicine" Approach.Clinics in perinatology · 2024Review
- Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device.Frontiers in pediatrics · 2024Article
- Oxygen in the neonatal ICU: a complicated history and where are we now?Frontiers in pediatrics · 2024Review
- Averaging Times for Pulse Oximeter Measurements - A Review of Manuscripts Published in the Top Five Sleep Medicine Journals.Nature and science of sleep · 2024Review
- Pathophysiology of Retinopathy of Prematurity.Annual review of vision science · 2023Review
- Effects of semi-upright swings on vital signs in NICU infants.Pediatric research · 2023Article
- Similar adverse outcome rates with high or low oxygen saturation targets in an area with low background mortality.Frontiers in pediatrics · 2023Article
- Endotypes of Prematurity and Phenotypes of Bronchopulmonary Dysplasia: Toward Personalized Neonatology.Journal of personalized medicine · 2022Review
- Factors to Consider to Study Preductal Oxygen Saturation Targets in Neonatal Pulmonary Hypertension.Children (Basel, Switzerland) · 2022Review
- Automated Oxygen Delivery in Neonatal Intensive Care.Frontiers in pediatrics · 2022Review
- Decoupling Oxygen Tension From Retinal Vascularization as a New Perspective for Management of Retinopathy of Prematurity. New Opportunities From β-adrenoceptors.Frontiers in pharmacology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
contextThe optimal oxygen saturation target for extremely preterm infants remains unclear.
objectiveTo systematically review evidence evaluating the effect of lower (85%-89%) versus higher (91%-95%) pulse oxygen saturation (Spo DATA SOURCES: Electronic databases and all published randomized trials evaluating lower versus higher Spo STUDY SELECTION: A total of 2896 relevant citations were identified; 5 trials were included in the final analysis. DATA EXTRACTION: Data from 5 trials were analyzed for quality of evidence and risk of bias. LIMITATIONS: Limitations include heterogeneity in age at enrollment and comorbidities between trials and change in oximeter algorithm midway through 3 trials.
resultsThere was no difference in the incidence of primary outcome (death/NDI at 18-24 months) in the 2 groups; risk ratio,1.05, 95% confidence interval 0.98-1.12, P = .18. Mortality before 18 to 24 months was higher in the lower-target group (risk ratio,1.16, 95% confidence interval 1.03-1.31, P = .02). Rates of NDI and severe visual loss did not differ between the 2 groups. Proportion of time infants spent outside the target range while on supplemental oxygen ranged from 8.2% to 27.4% <85% and 8.1% to 22.4% >95% with significant overlap between the 2 groups.
conclusionsThere was no difference in primary outcome between the 2 Spo
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.