ArticleThe Journal of clinical investigation1989
Humoral immune response to influenza vaccination in patients with primary immunoglobulin A nephropathy. An analysis of isotype distribution and size of the influenza-specific antibodies.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
- Epidemiology of Immune-Mediated Glomerulopathies before and after SARS-CoV-2 Vaccination: A Tertiary Referral Hospital Experience.Journal of clinical medicine · 2023Article
- Highly pathogenic coronaviruses and the kidney.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Intrinsic Kidney Pathology in Children and Adolescents Following COVID-19 Vaccination: A Systematic Review.Children (Basel, Switzerland) · 2022Review
- Gross hematuria can be an impact of severe acute respiratory syndrome coronavirus 2 vaccination on immunoglobulin A nephropathy: a case report.Journal of medical case reports · 2022Article
- IgA nephropathy relapse following COVID-19 vaccination treated with corticosteroid therapy: case report.BMC nephrology · 2022Article
- The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A systematic review.Journal of Taibah University Medical Sciences · 2022Review
- COVID-19 vaccination followed by activation of glomerular diseases: does association equal causation?Kidney international · 2021Article
- New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review.Vaccines · 2021Review
- Study of tonsillectomy for IgA nephropathy patients: short- and longer-term observation.International urology and nephrology · 2014Article
- Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.PloS one · 2014Article
- Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy.PloS one · 2014Article
- Henoch-Schönlein purpura in a renal transplant recipient with prior IgA nephropathy following influenza vaccination.Clinical kidney journal · 2013Article
- Development of a model of early-onset IgA nephropathy.Journal of the American Society of Nephrology : JASN · 2012Article
- Genetics and immunopathogenesis of IgA nephropathy.Clinical reviews in allergy & immunology · 2011Review
- Pathological role of tonsillar B cells in IgA nephropathy.Clinical & developmental immunology · 2011Review
- Different pathological roles of toll-like receptor 9 on mucosal B cells and dendritic cells in murine IgA nephropathy.Clinical & developmental immunology · 2011Article
- Secretory immunoglobulin A (IgA) responses in IgA nephropathy patients after mucosal immunization, as part of a polymeric IgA response.Clinical and experimental immunology · 2008Article
- Immunopathogenesis of IgAN.Seminars in immunopathology · 2007Review
- For further investigations in IgA nephropathy the approach from phenotype to genotype is welcome.Clinical and experimental immunology · 2002Article
- Expression of T cell receptor variable region families by bone marrow gammadelta T cells in patients with IgA nephropathy.Clinical and experimental immunology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary IgA nephropathy (IgAN) is characterized by mesangial deposits of IgA1, increased serum IgA1 levels, and circulating immune complexes containing predominantly IgA1. It has previously been found that patients with IgAN have a higher than normal IgA response to vaccination, but the IgA subclasses have not been studied. To investigate whether the IgA hyperresponsiveness is limited to the subclass IgA1, which is involved in the pathogenesis of IgAN, we compared the immune responses of 18 patients with 22 healthy controls after intramuscular vaccination with inactivated influenza virus. Antibody titers were significantly higher (P less than 0.0001) for the IgA1 subclass in patients versus controls, but not for the other isotypes. A substantial portion of the IgA and IgA1 antiinfluenza immune response comprised polymers in both patients and controls. There was no preferential response of polymers in patients. Patients produced significantly more monomeric IgA1 antibodies than controls. These results show that patients with IgAN have a hyperresponsiveness limited to the subclass IgA1 and mainly expressed by an excess of monomers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.