ArticleBrain, behavior, and immunity2017
Inflammation-induced anorexia and fever are elicited by distinct prostaglandin dependent mechanisms, whereas conditioned taste aversion is prostaglandin independent.
Article in Brain, behavior, and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits.Cell reports · 2026Article
- Dynamic changes in nutritional parameters, inflammatory, and immune biomarkers during (chemo-) radiotherapy for head and neck cancer: a prospective longitudinal study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Progranulin modulates inflammatory responses to immune challenges by suppressing circulating cytokine levels.Brain, behavior, & immunity - health · 2025Article
- GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits.bioRxiv : the preprint server for biology · 2025Article
- Antipyretic Mechanism of Bai Hu Tang on LPS-Induced Fever in Rat: A Network Pharmacology and Metabolomics Analysis.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Identification of Genes in Diagnosing Major Depressive Disorder with Anorexia Through Bioinformatics Analysis.Neuropsychiatric disease and treatment · 2025Article
- Relationship between calcium dynamics and inflammatory status in the transition period of dairy cows.JDS communications · 2023Review
- Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity.Diabetes · 2023Article
- The efficacy of fat-free mass index and appendicular skeletal muscle mass index in cancer malnutrition: a propensity score match analysis.Frontiers in nutrition · 2023Article
- Neural circuits mediating circulating interleukin-1β-evoked fever in the absence of prostaglandin E2 production.Brain, behavior, and immunity · 2022Article
- Review
- LPS induces rapid increase in GDF15 levels in mice, rats, and humans but is not required for anorexia in mice.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Differences between inflamed and non inflamed appendices diagnosed as acute appendicitis.Annals of medicine and surgery (2012) · 2021Article
- Malnutrition in cirrhosis: More food for thought.World journal of hepatology · 2020Review
- NF-κB signaling in tanycytes mediates inflammation-induced anorexia.Molecular metabolism · 2020Article
- New Insights into the Role of Glutathione in the Mechanism of Fever.International journal of molecular sciences · 2020Review
- Association of Exposure to Infections in Childhood With Risk of Eating Disorders in Adolescent Girls.JAMA psychiatry · 2019Article
- Age-Associated Changes in the Immune System and Blood⁻Brain Barrier Functions.International journal of molecular sciences · 2019Review
- Neural Mechanisms of Inflammation-Induced Fever.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Inflammation-induced motivational changes: Perspective gained by evaluating positive and negative valence systems.Current opinion in behavioral sciences · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammation evokes an array of brain-mediated responses including fever, anorexia and taste aversion. Both fever and anorexia are prostaglandin dependent but it has been unclear if the cell-type that synthesizes the critical prostaglandins is the same. Here we show that pharmacological inhibition or genetic deletion of cyclooxygenase (COX)-2, but not of COX-1, attenuates inflammation-induced anorexia. Mice with deletions of COX-2 selectively in brain endothelial cells displayed attenuated fever, as demonstrated previously, but intact anorexia in response to peripherally injected lipopolysaccharide (10μg/kg). Whereas intracerebroventricular injection of a cyclooxygenase inhibitor markedly reduced anorexia, deletion of COX-2 selectively in neural cells, in myeloid cells or in both brain endothelial and neural cells had no effect on LPS-induced anorexia. In addition, COX-2 in myeloid and neural cells was dispensable for the fever response. Inflammation-induced conditioned taste aversion did not involve prostaglandin signaling at all. These findings collectively show that anorexia, fever and taste aversion are triggered by distinct routes of immune-to-brain signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.