Evidence map›Paper›PMID 27940077›Full record

ArticleNeuropharmacology2017

The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA

Megan J Moerke, Andy Z X Zhu, Rachel F Tyndale, Martin A Javors, Lance R McMahon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Stimulus functions of nicotine.Advances in pharmacology (San Diego, Calif.) · 2022
    Article
  3. Article
  4. Enhancement of Opioid Antinociception by Nicotinic Ligands.The Journal of pharmacology and experimental therapeutics · 2021
    Article
  5. Review
  6. Review
  7. Enhancement of Opioid Antinociception by Nicotine.The Journal of pharmacology and experimental therapeutics · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Megan J MoerkeDepartment of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA.
Andy Z X ZhuCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Department of Pharmacology and Toxicology, and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Rachel F TyndaleCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Department of Pharmacology and Toxicology, and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Martin A JavorsDepartment of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA.
Lance R McMahonDepartment of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA. Electronic address: mcmahonl@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USCentre for Addiction and Mental Health · CAThe University of Texas Health Science Center · USUniversity of Toronto · CA

Funding

Nicotine dependence: neuropharmacology in monkeysR01DA025267 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MCMAHON, LANCE R. · 2009 to 2018
$3.4M
NIDA NIH HHS R01 DA025267
6 · The paper itself

Abstract

Quantitative analysis of antagonism is infrequently used to identify nAChRs mediating behavioral effects. Here, nicotine (0.032 mg/kg i.v.) was established as a discriminative stimulus in rhesus monkeys responding under a fixed ratio 5 schedule; pharmacokinetics and underlying nAChR mechanism(s) were examined. When measured up to 4 h in venous blood, the training dose resulted in the following mean pharmacokinetic parameters: nicotine C

Indexed as

Administration, IntravenousAnimalsConditioning, OperantCotinineDihydro-beta-ErythroidineDiscrimination LearningDose-Response Relationship, DrugDrug Administration ScheduleElectroshockFemaleMacaca mulattaMaleNicotineNicotinic AgonistsSmokingVareniclineCotinineDihydro-beta-ErythroidinehydroxycotinineNicotineNicotinic AgonistsVareniclineDHβEdihydro-β-erythroidineDrug discriminationfixed ratioFRmethyllycaconitineMLAnAChRNicotinenicotinic acetylcholine receptorRhesus monkeySchild analysisVarenicline

Identifiers

PMID27940077
PMCPMC5385163
OpenAlexW2560732780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.