ArticleInternational journal for parasitology2017
Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance.
Article in International journal for parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database.Parasite (Paris, France) · 2020Pooled it
- Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected withVeterinary sciences · 2026Article
- Development of a qPCR assay for Fasciola spp. identification and a deep amplicon sequencing method for differentiation of fluke species in UK livestock.PLoS neglected tropical diseases · 2026Article
- Multi-marker analysis ofParasitology · 2025Article
- Genetic diversity and population structure of Fasciola gigantica isolated from cattle in Malawi.Veterinary research communications · 2025Article
- Population genetic analysis of the liver fluke Fasciola hepatica in German dairy cattle reveals high genetic diversity and associations with fluke size.Parasites & vectors · 2025Article
- Pilot study on the population genetics structure ofFrontiers in veterinary science · 2025Article
- Genetic characterization of Fasciola hepatica (Linnaeus, 1758) in cattle from Paraná, Brazil.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025Article
- Identification of Novel Antileishmanial Chemotypes By High-Throughput Virtual and In Vitro Screening.Acta parasitologica · 2024Article
- Advancement in Diagnosis, Treatment, and Vaccines againstPathogens (Basel, Switzerland) · 2024Review
- Human fascioliasis emergence in southern Asia: Complete nuclear rDNA spacer and mtDNA gene sequences prove Indian patient infection related to fluke hybridization in northeastern India and Bangladesh.One health (Amsterdam, Netherlands) · 2024Article
- Intra- and interspecies variation and population dynamics of Fasciola gigantica among ruminants in Sudan.Parasitology research · 2024Article
- Fascioliasis.Advances in experimental medicine and biology · 2024Article
- Efficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms.International journal for parasitology. Drugs and drug resistance · 2023Article
- Genetic variation and population structure of Fasciola hepatica: an in silico analysis.Parasitology research · 2023Article
- Hatchability ofPathogens (Basel, Switzerland) · 2023Article
- A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.PLoS pathogens · 2023Article
- Molecular Characterization ofInfection and drug resistance · 2023Article
- Economic losses, morpho-molecular identification, and identity ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Fasciolosis-An Increasing Challenge in the Sheep Industry.Animals : an open access journal from MDPI · 2022Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Fasciola hepatica, the liver fluke, is a trematode parasite of considerable economic importance to the livestock industry and is a re-emerging zoonosis that poses a risk to human health in F. hepatica-endemic areas worldwide. Drug resistance is a substantial threat to the current and future control of F. hepatica, yet little is known about how the biology of the parasite influences the development and spread of resistance. Given that F. hepatica can self-fertilise and therefore inbreed, there is the potential for greater population differentiation and an increased likelihood of recessive alleles, such as drug resistance genes, coming together. This could be compounded by clonal expansion within the snail intermediate host and aggregation of parasites of the same genotype on pasture. Alternatively, widespread movement of animals that typically occurs in the UK could promote high levels of gene flow and prevent population differentiation. We identified clonal parasites with identical multilocus genotypes in 61% of hosts. Despite this, 84% of 1579 adult parasites had unique multilocus genotypes, which supports high levels of genotypic diversity within F. hepatica populations. Our analyses indicate a selfing rate no greater than 2%, suggesting that this diversity is in part due to the propensity for F. hepatica to cross-fertilise. Finally, although we identified high genetic diversity within a given host, there was little evidence for differentiation between populations from different hosts, indicating a single panmictic population. This implies that, once those emerge, anthelmintic resistance genes have the potential to spread rapidly through liver fluke populations.
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