ArticleBone2017
Maternal vitamin D biomarkers are associated with maternal and fetal bone turnover among pregnant women consuming controlled amounts of vitamin D, calcium, and phosphorus.
Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Bone turnover in pregnancy, measured by urinary CTX, is influenced by vitamin D supplementation and is associated with maternal bone health: findings from the Maternal Vitamin D Osteoporosis Study (MAVIDOS) trial.The American journal of clinical nutrition · 2021Trial
- Vitamin D binding protein rs7041 genotype alters vitamin D metabolism in pregnant women.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Trial
- Impact of Maternal Vitamin D Levels on Offspring Bone Development: Systematic Review.Journal of bone metabolism · 2026Article
- Pregnancy and lactation associated osteoporotic vertebral fracture: the neurosurgical perspective through a multicentric study.Neurosurgical review · 2024Article
- Prenatal but not continued postpartum vitamin D supplementation reduces maternal bone resorption as measured by C-terminal telopeptide of type 1 collagen without effects on other biomarkers of bone metabolism.Endocrine and metabolic science · 2024Article
- Mediterranean diet adherence and dietary calcium intake in a group of pregnant women: Results of an Italian survey.Food science & nutrition · 2021Article
- The role of vitamin D in perinatology. An up-to-date review.Archives of medical science : AMS · 2021Article
- The importance of maternal pregnancy vitamin D for offspring bone health: learnings from the MAVIDOS trial.Therapeutic advances in musculoskeletal disease · 2021Review
- Factors Influencing Vitamin D Levels in Neonatal Umbilical Cord Blood: A Two-Center Study From Tibet and Shenyang.Frontiers in pediatrics · 2020Article
- Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.Italian journal of pediatrics · 2018Review
- Idiopathic Hypoparathyroidism and Severe Hypocalcemia in Pregnancy.Case reports in endocrinology · 2018Article
- Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study.PloS one · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Vitamin D plays a central role in calcium homeostasis; however, its relationship with bone turnover during pregnancy remains unclear due to a lack of studies that have rigorously controlled for vitamin D and other nutrients known to influence bone metabolism. Similarly, prior investigations of the effect of pregnancy on bone turnover relative to the nonpregnant state may have been confounded by varying intakes of these nutrients. Nested within a controlled intake study, the present investigation sought to quantify associations between maternal vitamin D biomarkers and biochemical markers of bone turnover among pregnant (versus nonpregnant) women and their fetuses under conditions of equivalent and adequate intakes of vitamin D and related nutrients. Changes in markers of bone turnover across the third trimester were also examined. Healthy pregnant (26-29 wk gestation; n=26) and nonpregnant (n=21) women consumed 511IU vitamin D/d, 1.6g calcium/d, and 1.9g phosphorus/d for 10weeks while participating in a controlled feeding study featuring two choline doses. Based on linear mixed models adjusted for influential covariates (e.g., BMI, ethnicity, and season), pregnant women had 50-150% higher (P<0.001) concentrations of bone resorption markers than nonpregnant women. Among pregnant women, increases in maternal 25(OH)D across the study period were associated (P<0.020) with lower osteocalcin and deoxypyridinoline at study-end, and higher fetal osteocalcin. In addition, maternal free 25(OH)D, 1,25(OH)
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