Evidence map›Paper›PMID 27939821›Full record

ReviewTrends in neurosciences2017

Multimodal Imaging of Neurometabolic Pathology due to Traumatic Brain Injury.

John Darrell Van Horn, Avnish Bhattrai, Andrei Irimia

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
  2. Parallel detection of MRI andMagnetic resonance in medicine · 2025
    Article
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  4. Review
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  12. Review
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  14. Article
  15. VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-Oxidative medicine and cellular longevity · 2020
    Article
  16. Review
  17. Neuroimaging of traumatic brain injury in military personnel: An overview.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2019
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John Darrell Van HornUSC Mark and Mary Stevens Neuroimaging and Informatics Institute, 2025 Zonal Avenue, Keck School of Medicine of USC, University of Southern California, Los Angeles, California 90033, USA. Electronic address: jvanhorn@usc.edu.
Avnish BhattraiUSC Mark and Mary Stevens Neuroimaging and Informatics Institute, 2025 Zonal Avenue, Keck School of Medicine of USC, University of Southern California, Los Angeles, California 90033, USA.
Andrei IrimiaUSC Mark and Mary Stevens Neuroimaging and Informatics Institute, 2025 Zonal Avenue, Keck School of Medicine of USC, University of Southern California, Los Angeles, California 90033, USA.
University of Southern California · US

Funding

Multimodality Image-Based Assessment System for Traumatic Brain InjuryR44NS081792 · NINDS · KITWARE, INC. · PI AYLWARD, STEPHEN R, NIETHAMMER, MARC · 2015 to 2016
$1.3M
NINDS NIH HHS R44 NS081792
6 · The paper itself

Abstract

The impact of traumatic brain injury (TBI) involves a combination of complex biochemical processes beginning with the initial insult and lasting for days, months and even years post-trauma. These changes range from neuronal integrity losses to neurotransmitter imbalance and metabolite dysregulation, leading to the release of pro- or anti-apoptotic factors which mediate cell survival or death. Such dynamic processes affecting the brain's neurochemistry can be monitored using a variety of neuroimaging techniques, whose combined use can be particularly useful for understanding patient-specific clinical trajectories. Here, we describe how TBI changes the metabolism of essential neurochemical compounds, summarize how neuroimaging approaches facilitate the study of such alterations, and highlight promising ways in which neuroimaging can be used to investigate post-TBI changes in neurometabolism.

Indexed as

Multimodal ImagingNeuroimagingAnimalsBrainBrain Injuries, TraumaticHumansNeuronsmetabolismneurochemistryneuroimagingpathologytraumatic brain injury (TBI)

Identifiers

PMID27939821
PMCPMC6492940
OpenAlexW2559797242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.