ArticleJournal of endodontics2017
Viral MicroRNAs Identified in Human Dental Pulp.
Article in Journal of endodontics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Pooled it
- MicroRNA signatures in inflammatory dental tissues: biomarkers and molecular mechanisms.Frontiers in molecular biosciences · 2026Review
- Herpesvirus Simplex Virus-1 Exploits Inflammation to Infect Periodontal Stem Cells and Disrupt Lineage Commitment.Journal of periodontal research · 2025Article
- DNA virus tropism in healthy dental pulp: an in-situ reservoir site for torque teno virus and parvovirus B19.Journal of oral microbiology · 2025Article
- Article
- MicroRNA and their implications in dental pulp inflammation: current trends and future perspectives.Odontology · 2023Review
- Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia.Science advances · 2022Article
- Viruses of the oral cavity: Prevalence, pathobiology and association with oral diseases.Reviews in medical virology · 2022Review
- Human herpesvirus-encoded MicroRNA in host-pathogen interaction.Advances in biological regulation · 2021Review
- Covid-19 and oral diseases: Crosstalk, synergy or association?Reviews in medical virology · 2021Review
- Human and herpesvirus microRNAs in periodontal disease.Periodontology 2000 · 2021Review
- Research hotspots and trends of microRNA in periodontology and dental implantology: a bibliometric analysis.Annals of translational medicine · 2021Article
- Identification of microorganisms in irreversible pulpitis and primary endodontic infections with respect to clinical and radiographic findings.Clinical oral investigations · 2020Article
- Herpesvirus-bacteria synergistic interaction in periodontitis.Periodontology 2000 · 2020Review
- Viral MicroRNAs: Interfering the Interferon Signaling.Current pharmaceutical design · 2020Review
- Immunomodulatory roles of human herpesvirus-encoded microRNA in host-virus interaction.Reviews in medical virology · 2020Review
- Metalloproteinase 14 (MMP-14) and hsa-miR-410-3p expression in human inflamed dental pulp and odontoblasts.Histochemistry and cell biology · 2019Article
- Dysregulation of human miRNAs and increased prevalence of HHV miRNAs in obese periodontitis subjects.Journal of clinical periodontology · 2019Article
- Article
- Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection.Biochimica et biophysica acta. Gene regulatory mechanisms · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMicroRNAs (miRs) are a family of noncoding RNAs that regulate gene expression. They are ubiquitous among multicellular eukaryotes and are also encoded by some viruses. Upon infection, viral miRs (vmiRs) can potentially target gene expression in the host and alter the immune response. Although prior studies have reported viral infections in human pulp, the role of vmiRs in pulpal disease is yet to be explored. The purpose of this study was to examine the expression of vmiRs in normal and diseased pulps and to identify potential target genes.
methodsTotal RNA was extracted and quantified from normal and inflamed human pulps (N = 28). Expression profiles of vmiRs were then interrogated using miRNA microarrays (V3) and the miRNA Complete Labeling and Hyb Kit (Agilent Technologies, Santa Clara, CA). To identify vmiRs that were differentially expressed, we applied a permutation test.
resultsOf the 12 vmiRs detected in the pulp, 4 vmiRs (including those from herpesvirus and human cytomegalovirus) were differentially expressed in inflamed pulp compared with normal pulp (P < .05). Using bioinformatics, we identified potential target genes for the differentially expressed vmiRs. They included key mediators involved in the detection of microbial ligands, chemotaxis, proteolysis, cytokines, and signal transduction molecules.
conclusionsThese data suggest that miRs may play a role in interspecies regulation of pulpal health and disease. Further research is needed to elucidate the mechanisms by which vmiRs can potentially modulate the host response in pulpal disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.