Evidence map›Paper›PMID 27939721›Full record

ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2017

A bioenergetics assay for studying the effects of environmental stressors on mitochondrial function in vivo in zebrafish larvae.

Tara D Raftery, Nishad Jayasundara, Richard T Di Giulio

Abstract read
In one paragraph

Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tara D RafteryNicholas School of the Environment, Duke University, Durham, NC 27708, United States. Electronic address: tara.raftery@gmail.com.
Nishad JayasundaraNicholas School of the Environment, Duke University, Durham, NC 27708, United States.
Richard T Di GiulioNicholas School of the Environment, Duke University, Durham, NC 27708, United States.
Duke University · US

Funding

Zebrafish as a Detector of Organophosphate ExposureP42ES010356 · NIEHS · DUKE UNIVERSITY · PI AMY H HERRING · 2000 to 2026
$56.2M
NIEHS NIH HHS P42 ES010356
6 · The paper itself

Abstract

Mitochondria, an integral component of cellular energy metabolism and other key functions, are extremely vulnerable to damage by environmental stressors. Although methods to measure mitochondrial function in vitro exist, sensitive, medium- to high-throughput assays that assess respiration within physiologically-relevant whole organisms are needed to identify drugs and/or chemicals that disrupt mitochondrial function, particularly at sensitive early developmental stages. Consequently, we have developed and optimized an assay to measure mitochondrial bioenergetics in zebrafish larvae using the XF

Indexed as

AnimalsBenzo(a)pyreneCell RespirationDose-Response Relationship, DrugEnergy MetabolismEnvironmental PollutantsFluorenesHeart RateLarvaMetabolic Flux AnalysisMitochondriaOxygen ConsumptionPhenanthrenesPolycyclic Aromatic HydrocarbonsReproducibility of ResultsTime FactorsBenzo(a)pyreneEnvironmental PollutantsfluorantheneFluorenesphenanthrenePhenanthrenesPolycyclic Aromatic HydrocarbonsTriclosanBioenergeticsDevelopmentMitochondriaOxygen consumptionPolycyclic aromatic hydrocarbons (PAHs)RespirationTriclosanZebrafish

Identifiers

PMID27939721
PMCPMC5218841
OpenAlexW2559787695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.