ArticleOsteoarthritis and cartilage2017
The relationship between foot and ankle symptoms and risk of developing knee osteoarthritis: data from the osteoarthritis initiative.
Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Lateral wedges with and without custom arch support for people with medial knee osteoarthritis and pronated feet: an exploratory randomized crossover study.Journal of foot and ankle research · 2017Trial
- Altered knee joint loading in patients with chronic ankle instability during running.BMC sports science, medicine & rehabilitation · 2026Article
- Ankle Arthrodesis Associated With Risk of Progression to Total Knee Arthroplasty Compared to Total Ankle Arthroplasty.Foot & ankle orthopaedics · 2026Article
- Exploration of the causal association between osteoarthritis and ankle-foot diseases: evidence from the Mendelian randomization and colocalization analysis.Aging clinical and experimental research · 2025Article
- Article
- The Impact of Pes Planus on Knee Function and Its Association with Medial Compartment Knee Osteoarthritis.Journal of orthopaedic case reports · 2024Article
- Foot and knee deformities in relation to functional limitations and incident osteoarthritis: A prospective cohort study.Osteoporosis and sarcopenia · 2024Article
- Biomechanical response of lower limb joints to lateral wedge insoles.Scientific reports · 2024Article
- Changes in gastrocnemius MTU stiffness and their correlation with plantar pressure in patients with knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2024Article
- The prevalence of foot pain and association with baseline characteristics in people participating in education and supervised exercise for knee or hip osteoarthritis: a cross-sectional study of 26,003 participants from the GLA:D® registry.Journal of foot and ankle research · 2023Article
- Pairwise association of upper extremity musculoskeletal conditions: large population investigation from PERSIAN cohort study.Journal of orthopaedic surgery and research · 2023Article
- Take a load off: skeletal implications of sedentism in the feet of modern body donors.Evolution, medicine, and public health · 2023Article
- Foot and ankle pain and risk of incident knee osteoarthritis and knee pain: Data from the Multicentre Osteoarthritis Study.Osteoarthritis and cartilage open · 2021Article
- An exploration of changes in plantar pressure distributions during walking with standalone and supported lateral wedge insole designs.Journal of foot and ankle research · 2021Article
- Frontal plane knee alignment mediates the effect of frontal plane rearfoot motion on knee joint load distribution during walking in people with medial knee osteoarthritis.Osteoarthritis and cartilage · 2021Article
- Osteoarthritis Prevalence in Retired National Football League Players With a History of Ankle Injuries and Surgery.Journal of athletic training · 2019Article
- Anatomical Adaptation of Fibula and its Mechanism of Proximal Partial Fibulectomy Associated with Medial Compartment Knee Osteoarthritis.Orthopaedic surgery · 2019Article
- Clinical Assessment and Management of Foot and Ankle Osteoarthritis: A Review of Current Evidence and Focus on Pharmacological Treatment.Drugs & aging · 2019Review
- Longitudinal association between foot and ankle symptoms and worsening of symptomatic radiographic knee osteoarthritis: data from the osteoarthritis initiative.Osteoarthritis and cartilage · 2017Article
- Association of frontal plane knee alignment with foot posture in patients with medial knee osteoarthritis.BMC musculoskeletal disorders · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate whether foot and/or ankle symptoms increase the risk of developing (1) knee symptoms and (2) symptomatic radiographic knee osteoarthritis (OA).
design1020 Osteoarthritis Initiative (OAI) participants who were at-risk of knee OA, but were without knee symptoms or radiographic knee OA, were investigated. Participants indicated the presence and laterality of foot/ankle symptoms at baseline. The main outcome was development of knee symptoms (pain, aching or stiffness in and around the knee on most days of the month for at least 1 month in the past year). A secondary outcome was development of symptomatic radiographic knee OA (symptoms plus Kellgren and Lawrence [KL] grade ≥2), over the subsequent 4 years. Associations between foot/ankle symptoms and study outcomes were assessed by logistic regression models.
resultsFoot/ankle symptoms in either or both feet significantly increased the odds of developing knee symptoms (adjusted odds ratio (OR) 1.55, 95% confidence interval (CI) 1.10 to 2.19), and developing symptomatic radiographic knee OA (adjusted OR 3.28, 95% CI 1.69 to 6.37). Based on laterality, contralateral foot/ankle symptoms were associated with developing both knee symptoms (adjusted OR 1.68, 95% CI 1.05 to 2.68) and symptomatic radiographic knee OA (adjusted OR 3.08, 95% CI 1.06 to 8.98), whilst bilateral foot/ankle symptoms were associated with developing symptomatic radiographic knee OA (adjusted OR 4.02, 95% CI 1.76 to 9.17).
conclusionIn individuals at-risk of knee OA, the presence of contralateral foot/ankle symptoms in particular increases risk of developing both knee symptoms and symptomatic radiographic knee OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.