ArticleThe Journal of cell biology1989
The major component of the paraflagellar rod of Trypanosoma brucei is a helical protein that is encoded by two identical, tandemly linked genes.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Chronic constipation and the brain-gut-microbiome axis: the role of 5-HT signaling and Traditional Chinese Medicine in pathophysiology and treatment.Frontiers in medicine · 2025Review
- Structure, function and druggability of the African trypanosome flagellum.Journal of cellular physiology · 2022Review
- Structure of the trypanosome paraflagellar rod and insights into non-planar motility of eukaryotic cells.Cell discovery · 2021Article
- Evaluation of the Immunoprotective Potential of Recombinant Paraflagellar Rod Proteins ofVaccines · 2020Article
- Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense.PLoS neglected tropical diseases · 2016Article
- Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis.PloS one · 2016Article
- An overview on kinetoplastid paraflagellar rod.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Review
- Article
- Biochemical characterization of the bi-lobe reveals a continuous structural network linking the bi-lobe to other single-copied organelles in Trypanosoma brucei.The Journal of biological chemistry · 2013Article
- Article
- Independent analysis of the flagellum surface and matrix proteomes provides insight into flagellum signaling in mammalian-infectious Trypanosoma brucei.Molecular & cellular proteomics : MCP · 2011Article
- Retention and loss of RNA interference pathways in trypanosomatid protozoans.PLoS pathogens · 2010Article
- The N terminus of phosphodiesterase TbrPDEB1 of Trypanosoma brucei contains the signal for integration into the flagellar skeleton.Eukaryotic cell · 2010Article
- The paraflagellar rod of kinetoplastid parasites: from structure to components and function.International journal for parasitology · 2010Review
- Murine Models for Trypanosoma brucei gambiense disease progression--from silent to chronic infections and early brain tropism.PLoS neglected tropical diseases · 2009Article
- Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei.PLoS neglected tropical diseases · 2009Article
- Approaches for functional analysis of flagellar proteins in African trypanosomes.Methods in cell biology · 2009Article
- The flagellum of Trypanosoma brucei: new tricks from an old dog.International journal for parasitology · 2008Review
- Cryptic paraflagellar rod in endosymbiont-containing kinetoplastid protozoa.Eukaryotic cell · 2005Article
- Functional complementation of RNA interference mutants in trypanosomes.BMC biotechnology · 2005Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The flagellum of the parasitic hemoflagellate Trypanosoma brucei contains two major structures: (a) the microtubule axoneme, and (b) a highly ordered, filamentous array, the paraflagellar rod (PFR). This is a complex, three-dimensional structure, of yet unknown function, that extends along most of the axoneme and is closely linked to it. Its major structural component is a single protein of 600 amino acids. This PFR protein can assume two different conformations, resulting in two distinct bands of apparent molecular masses of 73 and 69 kD in SDS-gel electrophoresis. Secondary structure predictions indicate a very high helix content. Despite its biochemical similarity to the intermediate filament proteins (solubility properties, amino acid composition, and high degree of helicity), the PFR protein does not belong in this class of cytoskeletal proteins. The PFR protein is coded for by two tandemly linked genes of identical nucleotide sequence. Both genes are transcribed into stable mRNAs of very similar length that carry the mini-exon sequence at their 5' termini.
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