Evidence map›Paper›PMID 27939288›Full record

ArticleDiagnostic microbiology and infectious disease2017

Epidemiology and characteristics of Escherichia coli sequence type 131 (ST131) from long-term care facility residents colonized intestinally with fluoroquinolone-resistant Escherichia coli.

Jennifer H Han, Charles Garrigan, Brian Johnston, Irving Nachamkin, Connie Clabots, Warren B Bilker, Evelyn Santana, Pam Tolomeo, Joel Maslow, Janice Myers and 4 more

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Intestinal colonization due toAntimicrobial resistance and infection control · 2018
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jennifer H HanDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA. Electronic address: jennifer.han@uphs.upenn.edu.
Charles GarriganDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.
Brian JohnstonMinneapolis Veterans Affairs Medical Center, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN.
Irving NachamkinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.
Connie ClabotsMinneapolis Veterans Affairs Medical Center, Minneapolis, MN.
Warren B BilkerCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA.
Evelyn SantanaCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Pam TolomeoCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Joel MaslowGeneOne Life Science, Inc., Seoul, South Korea.
Janice MyersCoatesville Veterans Affairs Medical Center, Coatesville, PA.
Lesley CarsonDivision of Geriatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Ebbing LautenbachDivision of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA.
James R JohnsonMinneapolis Veterans Affairs Medical Center, Minneapolis, MN; Department of Medicine, University of Minnesota, Minneapolis, MN.
CDC Prevention Epicenters Program
University of Pennsylvania · USUniversity of Minnesota · USCoatesville Veterans Affairs Medical Center · USVeterans Health Administration · US

Funding

Quinolone resistant E coli in long term care facilitiesR01AG023792 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2005 to 2009
$2.8M
Mentoring and patient-oriented research in antimicrobial resistanceK24AI080942 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2009 to 2013
$853k
Carbapenem-Resistant Klebsiella Pneumoniae in Long-Term Acute Care HospitalsK01AI103028 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAN, JENNIFER · 2013 to 2017
$669k
Emergence of E. coli sequence type ST131I01CX000192 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI JOHNSON, JAMES R · 2009 to 2013
–
ACL HHS U54CK000163CSRD VA I01 CX000192NCEZID CDC HHS U54 CK000163NIAID NIH HHS K01 AI103028NIAID NIH HHS K24 AI080942NIA NIH HHS R01 AG023792
6 · The paper itself

Abstract

The objective of this study was to evaluate molecular and epidemiologic factors associated with Escherichia coli sequence type 131 (ST131) among long-term care facility (LTCF) residents who acquired gastrointestinal tract colonization with fluoroquinolone-resistant E. coli (FQREC). Colonizing isolates from 37 residents who newly developed FQREC colonization at three LTCFs from 2006 to 2008 were evaluated. Twenty-nine (78%) of 37 total FQREC colonizing isolates were ST131. Most ST131 isolates had a distinctive combination of gyrA and parC replacement mutations. The ST131 and non-ST131 isolates differed significantly for the prevalence of many individual virulence factors but not for the proportion that qualified molecularly as extraintestinal pathogenic E. coli (ExPEC) or aggregate virulence factor scores. E. coli ST131 was highly prevalent among LTCF residents with FQREC colonization. Future studies should determine the risk factors for infection among ST131-colonized residents, and assess the potential for increased transmissibility of ST131 in the long-term care setting.

Indexed as

Long-Term CareAgedAnti-Bacterial AgentsAsymptomatic InfectionsDNA, BacterialDNA GyraseDNA Topoisomerase IVDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsFemaleFluoroquinolonesGastrointestinal TractHumansMaleMicrobial Sensitivity TestsAnti-Bacterial AgentsDNA, BacterialDNA GyraseDNA Topoisomerase IVFluoroquinolonesVirulence FactorsEscherichia coliLong-term careST131

Identifiers

PMID27939288
PMCPMC5292283
OpenAlexW2558401290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.