Evidence map›Paper›PMID 27939182›Full record

ReviewTrends in pharmacological sciences2017

Implementing Precision Medicine: The Ethical Challenges.

Diane M Korngiebel, Kenneth E Thummel, Wylie Burke

Abstract readReview
In one paragraph

Review in Trends in pharmacological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Precision oncology: transforming cancer care through personalized medicine.Medical oncology (Northwood, London, England) · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Pharmacogenetics: Using science to reduce racial bias in pain management?Journal of the American Geriatrics Society · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diane M KorngiebelDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Wylie BurkeDepartment of Bioethics and Humanities, University of Washington, Seattle, WA, USA. Electronic address: wburke@u.washington.edu.

Funding

Pharmacogenetics in Rural and Underserved PopulationsU01GM092676 · NIGMS · UNIVERSITY OF WASHINGTON · PI BURKE, WYLIE G., THUMMEL, KENNETH E. · 2010 to 2014
$9.9M
Genomic Health Care and the Medically UnderservedP50HG003374 · NHGRI · UNIVERSITY OF WASHINGTON · PI BURKE, WYLIE G. · 2004 to 2014
$9.8M
Vitamin K gene network: Variant discovery and characterizationP01GM116691 · NIGMS · UNIVERSITY OF WASHINGTON · PI THUMMEL, KENNETH E. · 2016 to 2020
$7.6M
Ethically responsible clinical decision support for Lynch Syndrome screeningK01HG008180 · NHGRI · UNIVERSITY OF WASHINGTON · PI KORNGIEBEL, DIANE M · 2014 to 2018
$611k
NHGRI NIH HHS K01 HG008180NHGRI NIH HHS P50 HG003374NIGMS NIH HHS P01 GM116691NIGMS NIH HHS U01 GM092676
6 · The paper itself

Abstract

Precision medicine aims to individualize care by understanding differences in genetics, lifestyle, and environment. Pharmacogenomics and cancer genetics represent two promising areas for this approach. Pharmacogenomic tests have the potential to direct drug prescribing to increase safety and effectiveness because individuals vary on a genetic basis in their response to many drugs. Similarly, tests to identify people with an inherited cancer risk can guide prevention. For both, a few tests have entered clinical practice and more are under development. Implementation challenges include the limited evidence base available to guide clinical use and the lack of data from diverse populations. Accordingly, ongoing research should prioritize procedures that enhance the trustworthiness of clinical practice guidelines and create decision support for clinicians and patients that address their needs and accommodate flexibility. Each step involves choices with ethical implications.

Indexed as

Decision Support Systems, ClinicalHumansNeoplasmsPharmacogeneticsPractice Guidelines as TopicPrecision Medicinecancer geneticsclinical decision supportimplementation sciencepharmacogenomicsprecision medicine

Identifiers

PMID27939182
PMCPMC5217469

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.