Evidence map›Paper›PMID 27939058›Full record

Trial reportLancet (London, England)2017

A cleaner burning biomass-fuelled cookstove intervention to prevent pneumonia in children under 5 years old in rural Malawi (the Cooking and Pneumonia Study): a cluster randomised controlled trial.

Kevin Mortimer, Chifundo B Ndamala, Andrew W Naunje, Jullita Malava, Cynthia Katundu, William Weston, Deborah Havens, Daniel Pope, Nigel G Bruce, Moffat Nyirenda and 5 more

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Lancet (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 6 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Kevin MortimerMalawi Liverpool Wellcome Trust Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address: Kevin.mortimer@lstmed.ac.uk.
Chifundo B NdamalaMalawi Liverpool Wellcome Trust Programme, Blantyre, Malawi.
Andrew W NaunjeMalawi Liverpool Wellcome Trust Programme, Blantyre, Malawi.
Jullita MalavaMalawi Epidemiology and Intervention Research Unit, Chilumba, Malawi.
Cynthia KatunduMalawi Epidemiology and Intervention Research Unit, Chilumba, Malawi.
William WestonMalawi Liverpool Wellcome Trust Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK.
Deborah HavensLiverpool School of Tropical Medicine, Liverpool, UK.
Daniel PopeUniversity of Liverpool, Liverpool, UK.
Nigel G BruceUniversity of Liverpool, Liverpool, UK.
Moffat NyirendaMalawi Epidemiology and Intervention Research Unit, Chilumba, Malawi; London School of Hygiene & Tropical Medicine, London, UK.
Duolao WangLiverpool School of Tropical Medicine, Liverpool, UK.
Amelia CrampinMalawi Epidemiology and Intervention Research Unit, Chilumba, Malawi; London School of Hygiene & Tropical Medicine, London, UK.
Jonathan GriggQueen Mary University of London, London, UK.
John BalmesUniversity of California, Berkeley, CA, USA; University of California, San Francisco, CA, USA.
Stephen B GordonMalawi Liverpool Wellcome Trust Programme, Blantyre, Malawi; Liverpool School of Tropical Medicine, Liverpool, UK.

Funding

Medical Research Council MR/K006533/1Medical Research Council MR/L002515/1Medical Research Council MR/L009242/1Wellcome Trust 098610Wellcome Trust MR/K006533/1
6 · The paper itself

Abstract

backgroundWHO estimates exposure to air pollution from cooking with solid fuels is associated with over 4 million premature deaths worldwide every year including half a million children under the age of 5 years from pneumonia. We hypothesised that replacing open fires with cleaner burning biomass-fuelled cookstoves would reduce pneumonia incidence in young children.

methodsWe did a community-level open cluster randomised controlled trial to compare the effects of a cleaner burning biomass-fuelled cookstove intervention to continuation of open fire cooking on pneumonia in children living in two rural districts, Chikhwawa and Karonga, of Malawi. Clusters were randomly allocated to intervention and control groups using a computer-generated randomisation schedule with stratification by site, distance from health centre, and size of cluster. Within clusters, households with a child under the age of 4·5 years were eligible. Intervention households received two biomass-fuelled cookstoves and a solar panel. The primary outcome was WHO Integrated Management of Childhood Illness (IMCI)-defined pneumonia episodes in children under 5 years of age. Efficacy and safety analyses were by intention to treat. The trial is registered with ISRCTN, number ISRCTN59448623.

findingsWe enrolled 10 750 children from 8626 households across 150 clusters between Dec 9, 2013, and Feb 28, 2016. 10 543 children from 8470 households contributed 15 991 child-years of follow-up data to the intention-to-treat analysis. The IMCI pneumonia incidence rate in the intervention group was 15·76 (95% CI 14·89-16·63) per 100 child-years and in the control group 15·58 (95% CI 14·72-16·45) per 100 child-years, with an intervention versus control incidence rate ratio (IRR) of 1·01 (95% CI 0·91-1·13; p=0·80). Cooking-related serious adverse events (burns) were seen in 19 children; nine in the intervention and ten (one death) in the control group (IRR 0·91 [95% CI 0·37-2·23]; p=0·83).

interpretationWe found no evidence that an intervention comprising cleaner burning biomass-fuelled cookstoves reduced the risk of pneumonia in young children in rural Malawi. Effective strategies to reduce the adverse health effects of household air pollution are needed.

fundingMedical Research Council, UK Department for International Development, and Wellcome Trust.

Indexed as

BiomassAir Pollution, IndoorChild, PreschoolCookingFemaleFiresFollow-Up StudiesHumansIncidenceInfantMalawiMalePneumoniaRural HealthSingle-Blind MethodSmokeSmoke

Identifiers

PMID27939058
PMCPMC5783287

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.