ArticleSleep medicine
Associations between actigraphy-assessed sleep, inflammatory markers, and insulin resistance in the Midlife Development in the United States (MIDUS) study.
Article in Sleep medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Childhood paternal abuse and low paternal affection predict adult panic symptoms 18 years later via actigraphy-indexed sleep disruptions.Psychological medicine · 2026Article
- Actigraphy and subjective sleep predictors of nine-year generalized anxiety disorder.Journal of anxiety disorders · 2026Article
- Associations between self-reported and actigraphy measured sleep duration with metabolic syndrome: evidence from NHANES 2011-2014.Journal of behavioral medicine · 2025Article
- Housing insecurity pathways to physiological and epigenetic manifestations of health among aging adults: a conceptual model.Frontiers in public health · 2025Review
- Investigating the shared genetic architecture between frailty and insomnia.Frontiers in aging neuroscience · 2024Article
- Associations between Recession Hardships and Subjective and Objective Sleep Measures in the Midlife in the United States Study: Race and Gender Differences.Frontiers in sleep · 2024Article
- Article
- Editorial: Diet-sleep interaction on cardiometabolic health.Frontiers in public health · 2023Article
- Article
- The Cardiovascular Cost of Silence: Relationships Between Self-silencing and Carotid Atherosclerosis in Midlife Women.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022Article
- Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Inflammation, Oxidative Stress, and Antioxidant Micronutrients as Mediators of the Relationship Between Sleep, Insulin Sensitivity, and Glycosylated Hemoglobin.Frontiers in public health · 2022Article
- Beyond single sleep measures: A composite measure of sleep health and its associations with psychological and physical well-being in adulthood.Social science & medicine (1982) · 2021Article
- Linking discrimination and sleep with biomarker profiles: An investigation in the MIDUS study.Comprehensive psychoneuroendocrinology · 2021Article
- Sleep and Tau Pathology in Vietnam War Veterans with Preclinical and Prodromal Alzheimer's Disease.Journal of Alzheimer's disease reports · 2021Article
- Exposure to Phenols, Phthalates, and Parabens and Development of Metabolic Syndrome Among Mexican Women in Midlife.Frontiers in public health · 2021Article
- Modeling the cardiometabolic benefits of sleep in older women: exploring the 24-hour day.Sleep · 2020Article
- The Psychobiology of Bereavement and Health: A Conceptual Review From the Perspective of Social Signal Transduction Theory of Depression.Frontiers in psychiatry · 2020Review
- Links Between Stress, Sleep, and Inflammation: Are there Sex Differences?Current psychiatry reports · 2019Review
- Bereavement, Self-Reported Sleep Disturbances, and Inflammation: Results From Project HEART.Psychosomatic medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDisturbed sleep has been associated with increased insulin resistance and elevated inflammation. Although there is growing body of evidence that activation of inflammatory pathways plays a crucial role in the development of insulin resistance, the mediational model whereby sleep disturbances influence inflammation that drives insulin resistance has not been fully assessed in general population studies with objectively measured sleep. This study aimed to examine associations between objectively measured sleep, inflammatory markers, and insulin resistance simultaneously and in a mediational analysis, thereby offering insights into the possible causal model.
methodsCross-sectional data collected from 2004 to 2009 during the Midlife Development in the United States II biomarker project were used. The study population included 374 community-based participants (138 men and 236 women) who completed seven nights of wrist actigraphy. Multiple regressions controlling for age and statistically significant variables in univariate regressions were performed to evaluate the associations between actigraphy-assessed sleep measures, inflammatory cytokines, and insulin resistance.
resultsThe regression models showed that in women, higher sleep onset latency (SOL) was associated with higher insulin resistance after controlling for age, smoking, obesity, diabetes, depression, and inflammatory cytokines. Higher SOL was also associated with higher interleukin (IL)-6 and C-reactive protein (CRP) levels in women, but no association was found in men. Using mediation models in women, the association between SOL and insulin resistance was partially explained by the indirect effect of inflammatory cytokines.
conclusionA combination of inflammation and other unidentified pathways may contribute to the relationship between disturbed sleep and glucose homeostasis.
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