ArticleVeterinary microbiology2016
Mannheimia haemolytica biofilm formation on bovine respiratory epithelial cells.
Article in Veterinary microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Inhibitory effect of fluoroquinolones against biofilm formation by Staphylococcus aureus isolated from milk of dairy cows with mastitis.The Journal of veterinary medical science · 2026Article
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- Lactoferrin Affects the Viability of Bacteria in a Biofilm and the Formation of a New Biofilm Cycle ofInternational journal of molecular sciences · 2024Article
- Antimicrobial Activities of α-Helix andInternational journal of molecular sciences · 2024Article
- Identification, Biochemical Characterization, and In Vivo Detection of a Zn-Metalloprotease with Collagenase Activity fromInternational journal of molecular sciences · 2024Article
- Transcriptomic profiles of Mannheimia haemolytica planktonic and biofilm associated cells.PloS one · 2024Article
- Role of biofilms in antimicrobial resistance of the bacterial bovine respiratory disease complex.Frontiers in veterinary science · 2024Review
- Concordance of disk diffusion, broth microdilution, and whole-genome sequencing for determination of in vitro antimicrobial susceptibility of Mannheimia haemolytica.Journal of veterinary internal medicine · 2020Article
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- Association betweenVeterinary world · 2019Review
- Pathogenic Mannheimia haemolytica Invades Differentiated Bovine Airway Epithelial Cells.Infection and immunity · 2019Article
- Pathogenesis, Host Innate Immune Response, and Aerosol Transmission of Influenza D Virus in Cattle.Journal of virology · 2019Article
- Development and optimization of a differentiated airway epithelial cell model of the bovine respiratory tract.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mannheimia haemolytica is the most important bacterial agent associated with the bovine respiratory disease complex (BRDC), which causes worldwide economic losses to the cattle industry. M. haemolytica cells initially colonize the tonsillar crypts in the upper respiratory tract of cattle, from where they can subsequently descend into the lungs to cause disease. Many bacteria exist as biofilms inside their hosts. We hypothesize that M. haemolytica colonization of cattle during its commensal state may include biofilm formation. To begin to assess this possibility, we developed an in vitro system to study biofilm formation directly on bovine respiratory epithelial cells. Using fixed primary bovine bronchial epithelial cells, we observed M. haemolytica biofilm formation after a 48h incubation period at 37°C. Addition of mucin, the main component of mucus present in the upper respiratory tract, decreased M. haemolytica biofilm formation on bovine epithelial cells. We investigated the effects of prior viral infection of the epithelial cells on subsequent biofilm formation by M. haemolytica and found negligible effects. Utilization of this model system will provide new insights into the potential role of biofilm formation by M. haemolytica in the pathogenesis of BRDC.
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Registered trials
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