Evidence map›Paper›PMID 27938646›Full record

ArticleJournal of the International AIDS Society2016

Increased frequencies of CD8

Christine D Palmer, Marisol Romero-Tejeda, Eileen P Scully, Ainsley Lockhart, Michael S Seaman, Ariel Goldenthal, Alicja Piechocka-Trocha, Bruce D Walker, Lori B Chibnik, Stephanie Jost and 1 more

Abstract read
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In one paragraph

Article in Journal of the International AIDS Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christine D PalmerRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Marisol Romero-TejedaRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Eileen P ScullyRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Ainsley LockhartRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Michael S SeamanBeth Israel Deaconess Medical Center Boston, MA, USA.
Ariel GoldenthalRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Alicja Piechocka-TrochaRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Bruce D WalkerRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Lori B ChibnikProgram in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital Boston, MA, USA.
Stephanie JostRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Filippos PorichisRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

Funding

Molecular networks of HIV-specific CD4 T cell help to B cellsR01AI118544 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, BRUCE D · 2015 to 2019
$2.2M
Integrative analysis of genomic and epigenomic architecture in cognitive declineK25AG041906 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHIBNIK, LORI BETH · 2012 to 2016
$771k
NIAID NIH HHS R01 AI118544NIA NIH HHS K25 AG041906
6 · The paper itself

Abstract

introductionAn effective prophylactic vaccine against HIV will need to elicit antibody responses capable of recognizing and neutralizing rapidly evolving antigenic regions. The immunologic milieu associated with development of neutralizing antibody breadth remains to be fully defined. In this study, we sought to identify immunological signatures associated with neutralization breadth in HIV controllers. We applied an immune monitoring approach to analyze markers of T cell and myeloid cell activation by flow cytometry, comparing broad neutralizers with low- and non-neutralizers using multivariate and univariate analyses.

methodsAntibody neutralization breadth was determined, and cryopreserved peripheral blood mononuclear cells were stained for T cell and myeloid cell activation markers. Subjects were grouped according to neutralization breadth, and T cell and myeloid cell activation was analyzed by partial least squares discriminant analysis to determine immune signatures associated with high neutralization breadth.

resultsWe show that neutralization breadth in HIV viraemic controllers (VC) was strongly associated with increased frequencies of CD8

conclusionsOur data show elevated frequencies of CD8

Indexed as

AdultAIDS VaccinesAntibodies, NeutralizingCD4 Lymphocyte CountCD57 AntigensCD8-Positive T-LymphocytesFemaleHIV AntibodiesHIV InfectionsHumansImmunogenicity, VaccineLeukocytes, MononuclearMaleMiddle AgedViral LoadViremiaAIDS VaccinesAntibodies, NeutralizingCD57 AntigensHIV Antibodiesbiomarkerbroadly neutralizing antibodyHIVimmune monitoringimmune signatureT cellsviral load

Identifiers

PMID27938646
PMCPMC5149708

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.